Patrick O McGowan
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Explore the profile of Patrick O McGowan including associated specialties, affiliations and a list of published articles.
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56
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2418
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Recent Articles
1.
Rahman M, McGowan P
Transl Psychiatry
. 2022 Aug;
12(1):326.
PMID: 35948532
Early life stress (ELS) induces long-term phenotypic adaptations that contribute to increased vulnerability to a host of neuropsychiatric disorders. Epigenetic mechanisms, including DNA methylation, histone modifications and non-coding RNA, are...
2.
Hippocampus-Anterior Hypothalamic Circuit Modulates Stress-Induced Endocrine and Behavioral Response
Bang J, Zhao J, Rahman M, St-Cyr S, McGowan P, Kim J
Front Neural Circuits
. 2022 Jul;
16:894722.
PMID: 35795487
Hippocampal input to the hypothalamus is known to be critically involved in mediating the negative feedback inhibition of stress response. However, the underlying neural circuitry has not been fully elucidated....
3.
Sasaki A, Murphy K, Briollais L, McGowan P, Matthews S
PLoS One
. 2022 May;
17(5):e0267946.
PMID: 35500004
Maternal obesity is an important risk factor for childhood obesity and influences the prevalence of metabolic diseases in offspring. As childhood obesity is influenced by postnatal factors, it is critical...
4.
Eisha S, Joarder I, Wijenayake S, McGowan P
J Dev Orig Health Dis
. 2022 Apr;
13(6):665-673.
PMID: 35387707
Lactation is a critical time in mammalian development, where maternal factors shape offspring outcomes. In this scoping review, we discuss current literature concerning maternal factors that influence lactation biology and...
5.
Rahman M, Yuksel C, McGowan P
Brain Behav Immun
. 2022 Mar;
102:299-311.
PMID: 35259428
Both neonatal infections and exposure to maternal obesity are inflammatory stressors in early life linked to increased rates of psychopathologies related to mood and cognition. Epidemiological studies indicate that neonates...
6.
Abrego Del Castillo K, Dennis C, Wamithi S, Briollais L, McGowan P, Dol J, et al.
J Dev Orig Health Dis
. 2022 Jan;
13(5):541-549.
PMID: 34986920
Obesity rates among children are rapidly rising internationally and have been linked to noncommunicable diseases in adulthood. Individual preventive strategies have not effectively reduced global obesity rates, leading to a...
7.
Mathewson K, McGowan P, de Vega W, Morrison K, Saigal S, Van Lieshout R, et al.
Dev Psychobiol
. 2021 Dec;
63 Suppl 1:e22222.
PMID: 34964497
Long-term sequelae of extremely low birth weight (ELBW; ≤1000 g) may contribute to accelerated biological aging. This hypothesis was examined by analyzing a range of risk factors with a molecular...
8.
Briollais L, Rustand D, Allard C, Wu Y, Xu J, Rajan S, et al.
Clin Epigenetics
. 2021 Dec;
13(1):231.
PMID: 34937578
Background: The role of breastfeeding in modulating epigenetic factors has been suggested as a possible mechanism conferring its benefits on child development but it lacks evidence. Using extensive DNA methylation...
9.
Abuaish S, Lavergne S, Hing B, St-Cyr S, Spinieli R, Boonstra R, et al.
Proc Biol Sci
. 2021 Dec;
288(1964):20211908.
PMID: 34847769
Predation is a key organizing force in ecosystems. The threat of predation may act to programme the endocrine hypothalamic-pituitary-adrenal axis during development to prepare offspring for the environment they are...
10.
Wijenayake S, Eisha S, Tawhidi Z, Pitino M, Steele M, Fleming A, et al.
PLoS One
. 2021 Sep;
16(9):e0257633.
PMID: 34591894
Milk is a highly complex, heterogeneous biological fluid that contains non-nutritive, bioactive extracellular vesicles called exosomes. Characterization of milk-derived exosomes (MDEs) is challenging due to the lack of standardized methods...