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Richard L Simmons

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Articles 63
Citations 2297
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Recent Articles
1.
Tohme C, Haykal T, Yang R, Austin T, Loughran P, Geller D, et al.
Cells . 2024 Sep; 13(17. PMID: 39273020
Background: Exercise can promote sustainable protection against cold and warm liver ischemia-reperfusion injury (IRI) and tumor metastases. We have shown that this protection is by the induction of hepatic mitochondrial...
2.
Murthy P, Zenati M, AlMasri S, Desilva A, Singhi A, Paniccia A, et al.
J Natl Compr Canc Netw . 2023 Dec; 22(1D):e237070. PMID: 38150819
Background: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease characterized by chronic inflammation and a tolerogenic immune response. The granulocyte colony-stimulating factor (G-CSF)-neutrophil axis promotes oncogenesis and progression of PDAC....
3.
Mota Alvidrez R, Annarapu G, Srinivasan A, Liu Z, Yazdani H, Nolfi-Donegan D, et al.
J Pharm Pharmacol Res . 2023 Nov; 7(4):192-202. PMID: 37975061
Introduction: Metformin is the most prescribed medication in Diabetes Mellitus(DM). Metformin has shown to decrease mean platelet volume, with promising antiplatelet effects. High doses of Metformin have also been associated...
4.
Mota Alvidrez R, Annarapu G, Srinivasan A, Liu Z, Yazdani H, Simmons R, et al.
Res Sq . 2023 Jul; PMID: 37503167
Introduction: Metformin is the most prescribed medication in Diabetes Mellitus(DM). Metformin has shown to decrease mean platelet volume, with promising antiplatelet effects. High doses of Metformin have also been associated...
5.
Knatterud M, Simmons R, Payne W, Stock P, Chavers B, Ascher N, et al.
Clin Transplant . 2022 Dec; 37(3):e14877. PMID: 36528870
Dr John S Najarian (1927-2020), chairman of the Department of Surgery at the University of Minnesota from 1967 to 1993, was a pioneer in surgery, clinical immunology and transplantation. A...
6.
Kaltenmeier C, Yazdani H, Morder K, Geller D, Simmons R, Tohme S
Front Immunol . 2021 Dec; 12:785222. PMID: 34899751
While neutrophil extracellular traps (NETs) are important for directly promoting cancer growth, little is known about their impact on immune cells within the tumor microenvironment (TME). We hypothesize that NETs...
7.
Tohme S, Yazdani H, Rahman A, Handu S, Khan S, Wilson T, et al.
Can J Gastroenterol Hepatol . 2021 Dec; 2021:5212953. PMID: 34888264
Introduction: Hepatocellular carcinoma (HCC) accounts for approximately 90% of primary liver malignancies and is currently the fourth most common cause of cancer-related death worldwide. Due to varying underlying etiologies, the...
8.
Kaltenmeier C, Simmons R, Tohme S, Yazdani H
Cancers (Basel) . 2021 Dec; 13(23). PMID: 34885240
Metastasis is the leading cause of cancer related morbidity and mortality. The metastatic process involves several identifiable biological stages, including tumor cell dissemination, intravasation, and the extravasation of circulating cancer...
9.
Zamora R, Chavan S, Zanos T, Simmons R, Billiar T, Vodovotz Y
Mol Med . 2021 Jun; 27(1):65. PMID: 34167455
Background: Bacterial lipopolysaccharide (LPS) induces a multi-organ, Toll-like receptor 4 (TLR4)-dependent acute inflammatory response. Methods: Using network analysis, we defined the spatiotemporal dynamics of 20, LPS-induced, protein-level inflammatory mediators over...
10.
Azhar N, Namas R, Almahmoud K, Zaaqoq A, Malak O, Barclay D, et al.
Sci Rep . 2021 May; 11(1):9703. PMID: 33958628
Systemic inflammation is complex and likely drives clinical outcomes in critical illness such as that which ensues following severe injury. We obtained time course data on multiple inflammatory mediators in...