Richard L Leask
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Explore the profile of Richard L Leask including associated specialties, affiliations and a list of published articles.
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79
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1226
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Recent Articles
1.
Moeun B, Lemaire F, Smink A, Ebrahimi Orimi H, Leask R, de Vos P, et al.
J Tissue Eng
. 2025 Jan;
16:20417314241284826.
PMID: 39866963
Islet transplantation and more recently stem cell-derived islets were shown to successfully re-establish glycemic control in people with type 1 diabetes under immunosuppression. These results were achieved through intraportal infusion...
2.
Kennedy L, Bates K, Therrien J, Grossman Y, Kodaira M, Pressacco J, et al.
JACC Adv
. 2024 Jun;
2(8):100637.
PMID: 38938360
Background: Traditional methods of risk assessment for thoracic aortic aneurysm (TAA) based on aneurysm size alone have been called into question as being unreliable in predicting complications. Biomechanical function of...
3.
Moeun B, Fernandez S, Collin S, Gauvin-Rossignol G, Lescot T, Fortin M, et al.
3D Print Addit Manuf
. 2023 Oct;
10(5):869-886.
PMID: 37886415
A prominent obstacle in scaling up tissue engineering technologies for human applications is engineering an adequate supply of oxygen and nutrients throughout artificial tissues. Sugar glass has emerged as a...
4.
Campeau M, Leask R
Naunyn Schmiedebergs Arch Pharmacol
. 2023 Jul;
397(1):267-279.
PMID: 37421429
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have proven to be of therapeutic significance for cardiovascular diseases beyond the treatment of type 2 diabetes. Recent studies have demonstrated the beneficial effects of...
5.
Lee W, Boghdady C, Lelarge V, Leask R, McCaffrey L, Moraes C
Biomaterials
. 2023 Mar;
296:122073.
PMID: 36905756
Measuring internal mechanical stresses within 3D tissues can provide important insights into drivers of morphogenesis and disease progression. Cell-sized hydrogel microspheres have recently emerged as a powerful technique to probe...
6.
Campeau M, Leask R
Sci Rep
. 2022 Jul;
12(1):12681.
PMID: 35879337
The disruption of the endothelial cell (EC) glycocalyx (GCX) leads to cellular dysfunction promoting inflammation and cardiovascular disease progression. Recent studies have shown that empagliflozin (EMPA; Jardiance), a sodium-glucose cotransporter...
7.
Alakhtar A, Emmott A, Hart C, Mongrain R, Leask R, Lachapelle K
BMJ Simul Technol Enhanc Learn
. 2022 May;
7(6):536-542.
PMID: 35520974
Introduction: Three-dimensional (3D) printed multimaterial ascending aortic simulators were created to evaluate the ability of polyjet technology to replicate the distensibility of human aortic tissue when perfused at physiological pressures....
8.
Xuan Y, Alonso E, Emmott A, Wang Z, Kumar S, Mongeon F, et al.
J Thorac Cardiovasc Surg
. 2021 Sep;
164(6):1728-1738.e2.
PMID: 34538420
Objective: The Ross procedure is an excellent option for children or young adults who need aortic valve replacement because it can restore survival to that of the normal aged-matched population....
9.
Fernandez S, Danielczak L, Gauvin-Rossignol G, Hasilo C, Begin-Drolet A, Ruel J, et al.
Front Bioeng Biotechnol
. 2021 Jun;
9:674125.
PMID: 34124024
Transplantation of hydrogel-encapsulated pancreatic islets is a promising long-term treatment for type 1 diabetes that restores blood glucose regulation while providing graft immunoprotection. Most human-scale islet encapsulation devices that rely...
10.
Emmott A, Hertig V, Bergeron A, Villeneuve L, Lefebvre L, Leask R, et al.
Can J Cardiol
. 2020 Jun;
37(1):47-56.
PMID: 32544488
Background: Clinical studies have revealed a greater risk of pulmonary autograft dilation after the Ross procedure in patients with preoperative aortic insufficiency (AI). The present study examined whether the morphologic,...