Richard L Leask
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Explore the profile of Richard L Leask including associated specialties, affiliations and a list of published articles.
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79
Citations
1226
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Recent Articles
11.
Cooper S, Teoh H, Campeau M, Verma S, Leask R
Mol Cell Biochem
. 2019 May;
459(1-2):121-130.
PMID: 31127491
The antihyperglycemic agent empagliflozin not only improves glycemic control but has also been associated with clinically meaningful reductions in cardiovascular events. Studies have shown that empagliflozin significantly reduces cardiovascular death...
12.
Erythropel H, Bormann A, Nicell J, Leask R, Maric M
Polymers (Basel)
. 2019 Apr;
10(6).
PMID: 30966680
Several linear alkyl diol dibenzoate compounds, ranging from C3 to C6 in central diol length, were evaluated for their plasticizing effectiveness in blends with poly(vinyl chloride) (PVC). The results were...
13.
Jamarani R, Erythropel H, Nicell J, Leask R, Maric M
Polymers (Basel)
. 2019 Apr;
10(8).
PMID: 30960759
Plasticizers are additives that are used to impart flexibility to polymer blends and improve their processability. Plasticizers are typically not covalently bound to the polymers, allowing them to leach out...
14.
Lee W, Kalashnikov N, Mok S, Halaoui R, Kuzmin E, Putnam A, et al.
Nat Commun
. 2019 Jan;
10(1):144.
PMID: 30635553
Understanding how forces orchestrate tissue formation requires technologies to map internal tissue stress at cellular length scales. Here, we develop ultrasoft mechanosensors that visibly deform under less than 10 Pascals...
15.
Cooper S, Emmott A, McDonald K, Campeau M, Leask R
PLoS One
. 2018 Aug;
13(8):e0202526.
PMID: 30138400
Wall shear stress gradients (WSSGs) induce an inflammatory phenotype in endothelial cells (ECs) which is hypothesized to be mediated by mechanotransduction through the EC glycocalyx (GCX). We used a three-dimensional...
16.
Emmott A, Alzahrani H, Alreshidan M, Therrien J, Leask R, Lachapelle K
J Thorac Cardiovasc Surg
. 2018 Apr;
156(2):503-512.e1.
PMID: 29627182
Background: Clinical guidelines recommend resection of ascending aortic aneurysms at diameters 5.5 cm or greater to prevent rupture or dissection. However, approximately 40% of all ascending aortic dissections occur below...
17.
Garcia J, Yang Z, Mongrain R, Leask R, Lachapelle K
BMJ Simul Technol Enhanc Learn
. 2018 Jan;
4(1):27-40.
PMID: 29354281
3D printing is a new technology in constant evolution. It has rapidly expanded and is now being used in health education. Patient-specific models with anatomical fidelity created from imaging dataset...
18.
Shahmansouri N, Alreshidan M, Emmott A, Lachapelle K, El-Hamamsy I, Cartier R, et al.
Materials (Basel)
. 2017 Aug;
9(11).
PMID: 28773988
An aortic aneurysm is a lethal arterial disease that mainly occurs in the thoracic and abdominal regions of the aorta. Thoracic aortic aneurysms are prevalent in the root/ascending parts of...
19.
Emmott A, El-Hamamsy I, Leask R
Cardiovasc Pathol
. 2017 Jun;
29:48-52.
PMID: 28601673
Type A aortic dissection is an acute condition that requires urgent surgical intervention. However, in a subset of patients, aortic dissections go undiagnosed and become chronic, thereby allowing the dissected...
20.
Cooper S, McDonald K, Burkat D, Leask R
Ann Biomed Eng
. 2017 May;
45(9):2234-2243.
PMID: 28474270
Hemodynamic forces are known to be able to induce an inflammatory phenotype in endothelial cells (ECs). The EC glycocalyx (GCX) is a dynamic structure which is regulated in response to...