Richard Judson
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Explore the profile of Richard Judson including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Nyffeler J, Willis C, Harris F, Taylor L, Judson R, Everett L, et al.
Toxicol Appl Pharmacol
. 2022 Apr;
444:116032.
PMID: 35483669
The United States Environmental Protection Agency has proposed a tiered testing strategy for chemical hazard evaluation based on new approach methods (NAMs). The first tier includes in vitro profiling assays...
12.
Bundy J, Judson R, Williams A, Grulke C, Shah I, Everett L
BioData Min
. 2022 Mar;
15(1):7.
PMID: 35246223
Background: The advent of high-throughput transcriptomic screening technologies has resulted in a wealth of publicly available gene expression data associated with chemical treatments. From a regulatory perspective, data sets that...
13.
Sheffield T, Brown J, Davidson S, Paul Friedman K, Judson R
Bioinformatics
. 2021 Nov;
38(4):1157-1158.
PMID: 34791027
Summary: Many applications of chemical screening are performed in concentration or dose-response mode, and it is necessary to extract appropriate parameters, including whether the chemical/assay pair is active and if...
14.
Pradeep P, Judson R, DeMarini D, Keshava N, Martin T, Dean J, et al.
Comput Toxicol
. 2021 Sep;
18.
PMID: 34504984
Regulatory agencies world-wide face the challenge of performing risk-based prioritization of thousands of substances in commerce. In this study, a major effort was undertaken to compile a large genotoxicity dataset...
15.
Fantke P, Chiu W, Aylward L, Judson R, Huang L, Jang S, et al.
Int J Life Cycle Assess
. 2021 Jun;
26(5):899-915.
PMID: 34140756
Purpose: Reducing chemical pressure on human and environmental health is an integral part of the global sustainability agenda. Guidelines for deriving globally applicable, life cycle based indicators are required to...
16.
Pradeep P, Patlewicz G, Pearce R, Wambaugh J, Wetmore B, Judson R
Comput Toxicol
. 2021 Jun;
16.
PMID: 34124416
The toxicokinetic (TK) parameters fraction of the chemical unbound to plasma proteins and metabolic clearance are critical for relating exposure and internal dose when building in vitro-based risk assessment models....
17.
Pradeep P, Paul Friedman K, Judson R
Comput Toxicol
. 2021 May;
16(November 2020).
PMID: 34017928
Human health risk assessment for environmental chemical exposure is limited by a vast majority of chemicals with little or no experimental toxicity data. Data gap filling techniques, such as quantitative...
18.
Pham L, Watford S, Pradeep P, Martin M, Thomas R, Judson R, et al.
Comput Toxicol
. 2021 Jan;
15(August 2020):1-100126.
PMID: 33426408
New approach methodologies (NAMs) for chemical hazard assessment are often evaluated via comparison to animal studies; however, variability in animal study data limits NAM accuracy. The US EPA Toxicity Reference...
19.
Emara Y, Fantke P, Judson R, Chang X, Pradeep P, Lehmann A, et al.
Sci Total Environ
. 2021 Jan;
762:143874.
PMID: 33401053
Endocrine-disrupting chemicals have the ability to interfere with and alter functions of the hormone system, leading to adverse effects on reproduction, growth and development. Despite growing concerns over their now...
20.
Nyffeler J, Haggard D, Willis C, Setzer R, Judson R, Paul-Friedman K, et al.
SLAS Discov
. 2020 Sep;
26(2):292-308.
PMID: 32862757
Phenotypic profiling assays are untargeted screening assays that measure a large number (hundreds to thousands) of cellular features in response to a stimulus and often yield diverse and unanticipated profiles...