Richard J Weinberg
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Explore the profile of Richard J Weinberg including associated specialties, affiliations and a list of published articles.
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76
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5227
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Recent Articles
11.
Pappas A, Bey A, Wang X, Rossi M, Kim Y, Yan H, et al.
JCI Insight
. 2017 Oct;
2(20).
PMID: 29046483
Genetic defects in the synaptic scaffolding protein gene, SHANK2, are linked to a variety of neuropsychiatric disorders, including autism spectrum disorders, schizophrenia, intellectual disability, and bipolar disorder, but the molecular...
12.
Smith K, Jones K, Kopeikina K, Burette A, Copits B, Yoon S, et al.
J Neurosci
. 2017 Oct;
37(46):11127-11139.
PMID: 29030434
Appropriate excitatory/inhibitory (E/I) balance is essential for normal cortical function and is altered in some psychiatric disorders, including autism spectrum disorders (ASDs). Cell-autonomous molecular mechanisms that control the balance of...
13.
Plooster M, Menon S, Winkle C, Urbina F, Monkiewicz C, Phend K, et al.
Mol Biol Cell
. 2017 Jul;
28(18):2374-2385.
PMID: 28701345
Extracellular netrin-1 and its receptor deleted in colorectal cancer (DCC) promote axon branching in developing cortical neurons. Netrin-dependent morphogenesis is preceded by multimerization of DCC, activation of FAK and Src...
14.
Judson M, Burette A, Thaxton C, Pribisko A, Shen M, Rumple A, et al.
J Neurosci
. 2017 Jul;
37(31):7347-7361.
PMID: 28663201
Angelman syndrome (AS) is a debilitating neurodevelopmental disorder caused by loss of function of the maternally inherited allele. It is currently unclear how the consequences of this genetic insult unfold...
15.
Wu Y, Whiteus C, Xu C, Hayworth K, Weinberg R, Hess H, et al.
Proc Natl Acad Sci U S A
. 2017 Jun;
114(24):E4859-E4867.
PMID: 28559323
Close appositions between the membrane of the endoplasmic reticulum (ER) and other intracellular membranes have important functions in cell physiology. These include lipid homeostasis, regulation of Ca dynamics, and control...
16.
Xu C, Hayworth K, Lu Z, Grob P, Hassan A, Garcia-Cerdan J, et al.
Elife
. 2017 May;
6.
PMID: 28500755
Focused Ion Beam Scanning Electron Microscopy (FIB-SEM) can automatically generate 3D images with superior z-axis resolution, yielding data that needs minimal image registration and related post-processing. Obstacles blocking wider adoption...
17.
Simhal A, Aguerrebere C, Collman F, Vogelstein J, Micheva K, Weinberg R, et al.
PLoS Comput Biol
. 2017 Apr;
13(4):e1005493.
PMID: 28414801
Deeper exploration of the brain's vast synaptic networks will require new tools for high-throughput structural and molecular profiling of the diverse populations of synapses that compose those networks. Fluorescence microscopy...
18.
Uezu A, Kanak D, Bradshaw T, Soderblom E, Catavero C, Burette A, et al.
Science
. 2016 Sep;
353(6304):1123-9.
PMID: 27609886
Inhibitory synapses dampen neuronal activity through postsynaptic hyperpolarization. The composition of the inhibitory postsynapse and the mechanistic basis of its regulation, however, remain poorly understood. We used an in vivo...
19.
Dosemeci A, Weinberg R, Reese T, Tao-Cheng J
Front Synaptic Neurosci
. 2016 Sep;
8:23.
PMID: 27594834
The postsynaptic density (PSD), apparent in electron micrographs as a dense lamina just beneath the postsynaptic membrane, includes a deeper layer, the "pallium", containing a scaffold of Shank and Homer...
20.
Burette A, Judson M, Burette S, Phend K, Philpot B, Weinberg R
J Comp Neurol
. 2016 Jun;
525(2):233-251.
PMID: 27339004
Ubiquitination regulates a broad array of cellular processes, and defective ubiquitination is implicated in several neurological disorders. Loss of the E3 ubiquitin-protein ligase UBE3A causes Angelman syndrome. Despite its clinical...