Richard J Lin
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Explore the profile of Richard J Lin including associated specialties, affiliations and a list of published articles.
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83
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1065
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Recent Articles
1.
Corona M, Ip A, Brown S, Luna A, Khatib H, Flynn J, et al.
Bone Marrow Transplant
. 2025 Feb;
PMID: 39893244
CD19-directed chimeric antigen receptor T-cell (CAR-T) therapy has recently been approved as second-line treatment for relapsed/refractory large B-cell lymphoma (LBCL). This study compares patterns of disease relapse and progression across...
2.
Park J, Palomba M, Perica K, Devlin S, Shah G, Dahi P, et al.
J Clin Oncol
. 2025 Jan;
:JCO2402424.
PMID: 39883889
Purpose: We designed a CD19-targeted chimeric antigen receptor (CAR) comprising a calibrated signaling module, termed 1XX, that differs from that of conventional CD28/CD3ζ and 4-1BB/CD3ζ CARs. Preclinical data demonstrated that...
3.
Boardman A, Gutgarts V, Flynn J, Devlin S, Goldman A, Tomas A, et al.
Haematologica
. 2024 Nov;
110(3):651-664.
PMID: 39568416
Chimeric antigen receptor (CAR) T cells targeting CD19 induce durable remissions in patients with relapsed or refractory non-Hodgkin lymphoma (NHL), but many patients experience treatment-related toxicity. Cytokine release syndrome and...
4.
Melica G, Luna de Abia A, Shah G, Devlin S, Corona M, Fein J, et al.
Transplant Cell Ther
. 2024 Oct;
31(1):36-44.
PMID: 39448032
Patients undergoing CD19 chimeric antigen receptor (CAR)-T cell therapy exhibit multiple immune deficits that may increase their susceptibility to infections. Invasive fungal infections (IFIs) are life-threatening events in the setting...
5.
Hubbeling H, Leithner D, Silverman E, Flynn J, Devlin S, Shah G, et al.
Clin Cancer Res
. 2024 Sep;
30(22):5083-5093.
PMID: 39259292
Purpose: Greater disease burden is a well-established predictor of poorer outcomes following chimeric antigen receptor T-cell (CAR T) therapy. Although bridging therapy (BT) is widely used between leukapheresis and CAR...
6.
Lorenc R, Shouval R, Flynn J, Devlin S, Saldia A, Luna de Abia A, et al.
Transplant Cell Ther
. 2024 Jul;
30(10):990-1000.
PMID: 38972512
Chimeric antigen receptor (CAR) T cells are an established treatment for B cell non-Hodgkin lymphomas (B-NHL). With the remarkable success in improving survival, understanding the late effects of CAR T...
7.
Cederquist G, Schefflein J, Devlin S, Shah G, Shouval R, Hubbeling H, et al.
Blood Adv
. 2024 Jun;
8(19):5192-5199.
PMID: 38861344
Chimeric antigen receptor (CAR) T-cell therapy (CART) for central nervous system lymphoma (CNSL) is a promising strategy, yet responses are frequently not durable. Bridging radiotherapy (BRT) is used for extracranial...
8.
Shouval R, Goldman A, Flynn J, El-Moghraby A, Rehman M, Devlin S, et al.
Br J Haematol
. 2024 May;
205(3):978-989.
PMID: 38735683
Recent reports have raised concerns about the association of chimeric antigen receptor T cell (CAR-T) with non-negligible cardiotoxicity, particularly atrial arrhythmias. First, we conducted a pharmacovigilance study to assess the...
9.
Meyers G, Bubalo J, Eckstrom E, Winsnes K, Carpenter P, Artz A, et al.
Transplant Cell Ther
. 2024 Apr;
30(7):646-662.
PMID: 38663768
Acute encephalopathy, manifesting clinically as delirium, is a common but often unrecognized complication of hematopoietic cell transplantation (HCT). Delirium can occur in patients of any age and is observed after...
10.
Leithner D, Flynn J, Devlin S, Mauguen A, Fei T, Zeng S, et al.
J Hematol Oncol
. 2024 Apr;
17(1):21.
PMID: 38649972
Relapse and toxicity limit the effectiveness of chimeric antigen receptor T-cell (CAR-T) therapy for large B-cell lymphoma (LBCL), yet biomarkers that predict outcomes and toxicity are lacking. We examined radiomic...