Richard Huganir
Overview
Explore the profile of Richard Huganir including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
21
Citations
1051
Followers
0
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Chen K, Yang J, Liu B, Jiang C, Koylass N, Zhang Z, et al.
Cell Rep
. 2025 Feb;
44(2):115302.
PMID: 39946237
Hippocampal long-term potentiation (LTP) and long-term depression (LTD) are forms of synaptic plasticity, thought to be the molecular basis of learning and memory, dependent on dynamic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)...
2.
Araki Y, Rajkovich K, Gerber E, Gamache T, Johnson R, Tran T, et al.
Science
. 2024 Feb;
383(6686):eadk1291.
PMID: 38422154
SynGAP is an abundant synaptic GTPase-activating protein (GAP) critical for synaptic plasticity, learning, memory, and cognition. Mutations in in humans result in intellectual disability, autistic-like behaviors, and epilepsy. Heterozygous -knockout...
3.
Chen X, Jia B, Araki Y, Liu B, Ye F, Huganir R, et al.
Cell Res
. 2022 Jul;
32(10):914-930.
PMID: 35856091
In response to stimuli, the immediate early gene product Arc can acutely down-regulate synaptic strength by removing AMPA receptors (AMPARs) from synapses and thus regulate synaptic plasticity. How Arc, a...
4.
Zhang W, Chuang Y, Na Y, Ye Z, Yang L, Lin R, et al.
Mol Cell
. 2019 Jun;
75(1):13-25.e5.
PMID: 31151856
Arc is a synaptic protein essential for memory consolidation. Recent studies indicate that Arc originates in evolution from a Ty3-Gypsy retrotransposon GAG domain. The N-lobe of Arc GAG domain acquired...
5.
Han M, Mejias R, Chiu S, Rose R, Adamczyk A, Huganir R, et al.
Behav Brain Res
. 2017 Jan;
321:176-184.
PMID: 28063882
Glutamate receptor interacting proteins 1 and 2 (GRIP1/2) play an important role in regulating synaptic trafficking of AMPA receptor 2/3 (GluA2/3) and synaptic strength. Gain-of-function GRIP1 mutations are implicated in...
6.
Oh Y, Cho G, Li Z, Hong I, Zhu R, Kim M, et al.
Cell Stem Cell
. 2016 Jun;
19(1):95-106.
PMID: 27320040
Neurons derived from human pluripotent stem cells (hPSCs) are powerful tools for studying human neural development and diseases. Robust functional coupling of hPSC-derived neurons with target tissues in vitro is...
7.
Turner T, Sharma K, Oh E, Liu Y, Collins R, Sosa M, et al.
Nature
. 2015 Mar;
520(7545):51-6.
PMID: 25807484
Autism is a multifactorial neurodevelopmental disorder affecting more males than females; consequently, under a multifactorial genetic hypothesis, females are affected only when they cross a higher biological threshold. We hypothesize...
8.
Mignogna M, Giannandrea M, Gurgone A, Fanelli F, Raimondi F, Mapelli L, et al.
Nat Commun
. 2015 Mar;
6:6504.
PMID: 25784538
RAB39B is a member of the RAB family of small GTPases that controls intracellular vesicular trafficking in a compartment-specific manner. Mutations in the RAB39B gene cause intellectual disability comorbid with...
9.
Alfonso S, Kessels H, Banos C, Chan T, Lin E, Kumaravel G, et al.
Eur J Neurosci
. 2014 Apr;
39(7):1225-33.
PMID: 24713001
Amyloid beta (Aβ), a key component in the pathophysiology of Alzheimer's disease, is thought to target excitatory synapses early in the disease. However, the mechanism by which Aβ weakens synapses...
10.
Holst B, Madsen K, Jansen A, Jin C, Rickhag M, Lund V, et al.
PLoS Biol
. 2013 May;
11(4):e1001542.
PMID: 23630454
Secretory vesicles in endocrine cells store hormones such as growth hormone (GH) and insulin before their release into the bloodstream. The molecular mechanisms governing budding of immature secretory vesicles from...