Richard H Wade
Overview
Explore the profile of Richard H Wade including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
403
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Recent Articles
1.
Wade R
Mol Biotechnol
. 2009 Jul;
43(2):177-91.
PMID: 19565362
Microtubules are hollow tubes some 25 nm in diameter participating in the eukaryotic cytoskeleton. They are built from alphabeta-tubulin heterodimers that associate to form protofilaments running lengthwise along the microtubule...
2.
Wade R, Garcia-Saez I, Kozielski F
Mol Biotechnol
. 2009 Jan;
42(1):49-60.
PMID: 19130318
Structures of homologous proteins are usually conserved during evolution, as are critical active site residues. This is the case for actin and tubulin, the two most important cytoskeleton proteins in...
3.
Wade R
Methods Mol Med
. 2007 Dec;
137:1-16.
PMID: 18085218
Microtubules are found in all eukaryotes and are built from alphabeta-tubulin heterodimers. The alpha-tubulins and beta-tubulins are among the most highly conserved eukaryotic proteins. Other members of the tubulin family...
4.
Skoufias D, DeBonis S, Saoudi Y, Lebeau L, Crevel I, Cross R, et al.
J Biol Chem
. 2006 Mar;
281(26):17559-69.
PMID: 16507573
Human Eg5, responsible for the formation of the bipolar mitotic spindle, has been identified recently as one of the targets of S-trityl-L-cysteine, a potent tumor growth inhibitor in the NCI...
5.
Robin G, DeBonis S, Dornier A, Cappello G, Ebel C, Wade R, et al.
Biochemistry
. 2005 Apr;
44(17):6526-36.
PMID: 15850386
Kinesins form a superfamily of molecular motors involved in cell division and intracellular transport. Twenty kinesins have been found in the Caenorhabditis elegans genome, and four of these belong to...
6.
DeBonis S, Skoufias D, Lebeau L, Lopez R, Robin G, Margolis R, et al.
Mol Cancer Ther
. 2004 Sep;
3(9):1079-90.
PMID: 15367702
Human Eg5, a member of the kinesin superfamily, plays a key role in mitosis, as it is required for the formation of a bipolar spindle. We describe here the first...
7.
Garcia-Saez I, Yen T, Wade R, Kozielski F
J Mol Biol
. 2004 Jul;
340(5):1107-16.
PMID: 15236970
The human kinetochore is a highly complex macromolecular structure that connects chromosomes to spindle microtubules (MTs) in order to facilitate accurate chromosome segregation. Centromere-associated protein E (CENP-E), a member of...
8.
DeBonis S, Simorre J, Crevel I, Lebeau L, Skoufias D, Blangy A, et al.
Biochemistry
. 2003 Jan;
42(2):338-49.
PMID: 12525161
The microtubule-dependent kinesin-like protein Eg5 from Homo sapiens is involved in the assembly of the mitotic spindle. It shows a three-domain structure with an N-terminal motor domain, a central coiled...
9.
Wade R
Structure
. 2002 Oct;
10(10):1329-36.
PMID: 12377119
The three-dimensional structures of homologous proteins are usually conserved during evolution, as are critical residues in a few short sequence motifs that often constitute the active site in enzymes. The...