Richard G A Faragher
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Explore the profile of Richard G A Faragher including associated specialties, affiliations and a list of published articles.
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40
Citations
609
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Recent Articles
11.
Latorre E, Ostler E, Faragher R, Harries L
FASEB J
. 2018 Aug;
33(1):1086-1097.
PMID: 30088951
Cellular plasticity is a key facet of cellular homeostasis requiring correct temporal and spatial patterns of alternative splicing. Splicing factors, which orchestrate this process, demonstrate age-related dysregulation of expression; they...
12.
Burton D, Faragher R
Biogerontology
. 2018 Jul;
19(6):447-459.
PMID: 30054761
Cellular senescence is now considered as a major mechanism in the development and progression of various diseases and this may include metabolic diseases such as obesity and type-2 diabetes. The...
13.
Latorre E, Birar V, Sheerin A, Jeynes J, Hooper A, Dawe H, et al.
BMC Cell Biol
. 2017 Oct;
18(1):31.
PMID: 29041897
Background: Altered expression of mRNA splicing factors occurs with ageing in vivo and is thought to be an ageing mechanism. The accumulation of senescent cells also occurs in vivo with...
14.
Ibrahim B, Sheerin A, Jennert-Burston K, Bird J, Massala M, Illsley M, et al.
Exp Gerontol
. 2016 Aug;
83:139-47.
PMID: 27492502
Werner's syndrome (WS) is an autosomal recessive genetic disorder caused by loss of function mutation in wrn and is a useful model of premature in vivo ageing. Cellular senescence is...
15.
Nikolich-Zugich J, Goldman D, Cohen P, Cortese D, Fontana L, Kennedy B, et al.
J Gerontol A Biol Sci Med Sci
. 2015 Oct;
71(4):435-44.
PMID: 26419976
Although the demographic revolution has produced hundreds of millions people aged 65 and older, a substantial segment of that population is not enjoying the benefits of extended healthspan. Many live...
16.
Alimbetov D, Davis T, Brook A, Cox L, Faragher R, Nurgozhin T, et al.
Biogerontology
. 2015 Sep;
17(2):305-15.
PMID: 26400758
Senescent cells show an altered secretome profile termed the senescence-associated secretory phenotype (SASP). There is an increasing body of evidence that suggests that the accumulation of SASP-positive senescent cells in...
17.
Faragher R
Front Genet
. 2015 Aug;
6:171.
PMID: 26236330
The aging of the population represents one of the largest healthcare challenges facing the world today. The available scientific evidence shows that interventions are available now that can target fundamental...
18.
Birar V, Sheerin A, Milkovicova J, Faragher R, Ostler E
Chem Cent J
. 2015 May;
9:26.
PMID: 26023318
Background: Compounds based on trans-1,2-diphenylethene are the subject of intense interest both for their optical properties and as potential leads for drug discovery, as a consequence of their anticancer, anti-inflammatory...
19.
Sheerin A, Smith S, Jennert-Burston K, Brook A, Allen M, Ibrahim B, et al.
Aging Cell
. 2011 Dec;
11(2):234-40.
PMID: 22128747
The human cornea is a tri-laminar structure composed of several cell types with substantial mitotic potential. Age-related changes in the cornea are associated with declining visual acuity and the onset...
20.
Bird J, Jennert-Burston K, Bachler M, Mason P, Lowe J, Heo S, et al.
Biogerontology
. 2011 Jul;
13(1):49-62.
PMID: 21786128
WRN is a RecQ helicase with an associated exonuclease activity important in DNA metabolism, including DNA replication, repair and recombination. In humans, deficiencies in WRN function cause the segmental progeroid...