Richard E Carson
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Explore the profile of Richard E Carson including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Salardini E, ODell R, Tchorz E, Nabulsi N, Huang Y, Carson R, et al.
bioRxiv
. 2024 Oct;
PMID: 39386453
Background: The pathological effects of amyloid β oligomers (Aβo) may be mediated through the metabotropic glutamate receptor subtype 5 (mGluR5), leading to synaptic loss in Alzheimer's disease (AD). Positron emission...
12.
Matuskey D, Yang Y, Naganawa M, Koohsari S, Toyonaga T, Gravel P, et al.
Mol Psychiatry
. 2024 Oct;
PMID: 39367053
The neural bases of autism are poorly understood at the molecular level, but evidence from animal models, genetics, post-mortem studies, and single-gene disorders implicate synaptopathology. Here, we use positron emission...
13.
Young J, ODell R, Naganawa M, Toyonaga T, Chen M, Nabulsi N, et al.
J Nucl Med
. 2024 Sep;
65(11):1782-1785.
PMID: 39299782
Simplified methods of acquisition and quantification would facilitate the use of synaptic density imaging in multicenter and longitudinal studies of Alzheimer disease (AD). We validated a simplified tissue-to-reference ratio method...
14.
Bonomi R, Hillmer A, Woodcock E, Bhatt S, Rusowicz A, Angarita G, et al.
Proc Natl Acad Sci U S A
. 2024 Aug;
121(35):e2406005121.
PMID: 39172786
Dynamic brain immune function in individuals with posttraumatic stress disorder is rarely studied, despite evidence of peripheral immune dysfunction. Positron emission tomography brain imaging using the radiotracer [C]PBR28 was used...
15.
Naganawa M, Gallezot J, Li S, Nabulsi N, Henry S, Cai Z, et al.
Eur J Nucl Med Mol Imaging
. 2024 Aug;
52(1):113-121.
PMID: 39155309
Purpose: [F]SynVesT-1, a positron emission tomography (PET) radiotracer for the synaptic vesicle glycoprotein 2A (SV2A), demonstrates kinetics similar to [C]UCB-J, with high brain uptake, fast kinetics fitting well with the...
16.
Asch R, Abdallah C, Carson R, Esterlis I
Neuropsychopharmacology
. 2024 Jul;
50(1):153-163.
PMID: 39039139
The development of novel radiotracers for Positron Emission Tomography (PET) imaging agents targeting the synaptic vesicle glycoprotein 2 A (SV2A), an integral glycoprotein present in the membrane of all synaptic...
17.
Asch R, Worhunsky P, Davis M, Holmes S, Cool R, Boster S, et al.
J Affect Disord
. 2024 Jun;
361:415-424.
PMID: 38876317
Background: Elucidating biological mechanisms contributing to bipolar disorder (BD) is key to improved diagnosis and treatment development. With converging evidence implicating the metabotropic glutamate receptor 5 (mGlu5) in the pathology...
18.
Li H, Badawi R, Cherry S, Fontaine K, He L, Henry S, et al.
J Nucl Med
. 2024 Jun;
65(8):1320-1326.
PMID: 38871391
The collaboration of Yale, the University of California, Davis, and United Imaging Healthcare has successfully developed the NeuroEXPLORER, a dedicated human brain PET imager with high spatial resolution, high sensitivity,...
19.
Gu J, Zheng M, Holden D, Fowles K, Qiu L, Felchner Z, et al.
Res Sq
. 2024 Jun;
PMID: 38854065
Purpose: The sphingosine-1-phosphate receptor-1 (S1PR) is involved in regulating responses to neuroimmune stimuli. There is a need for S1PR-specific radioligands with clinically suitable brain pharmcokinetic properties to complement existing radiotracers....
20.
Fang X, Raval N, ODell R, Naganawa M, Mecca A, Chen M, et al.
Brain Commun
. 2024 Apr;
6(2):fcae107.
PMID: 38601916
Synaptic loss is a primary pathology in Alzheimer's disease and correlates best with cognitive impairment as found in studies. Previously, we observed reductions of synaptic density with [C]UCB-J PET (radiotracer...