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Richard D Grieve

Explore the profile of Richard D Grieve including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 13
Citations 1093
Followers 0
Related Specialties
General Medicine
Health Services
Biotechnology
Top 10 Co-Authors
David A Harrison
Paul R Mouncey
M Zia Sadique
Kathryn M Rowan
Alvin Richards-Belle
Alexina J Mason
J Duncan Young
Sheila E Harvey
Anthony C Gordon
Chris Whitman
Published In
Health Technol Assess
J Intensive Care Soc
Health Econ
JAMA
N Engl J Med
Affiliations
Soon will be listed here.
Recent Articles
1.
Evaluating the clinical and cost-effectiveness of permissive hypotension in critically ill patients aged 65 years or over with vasodilatory hypotension: Protocol for the 65 randomised clinical trial
Richards-Belle A, Mouncey P, Grieve R, Harrison D, Zia Sadique M, Henry D, et al.
J Intensive Care Soc . 2021 Jun; 21(4):281-282. PMID: 34093727
Vasodilatory shock is common in critically ill patients and vasopressors are a mainstay of therapy. A meta-analysis suggested that use of a higher, as opposed to a lower, mean arterial...
2.
Reduced exposure to vasopressors through permissive hypotension to reduce mortality in critically ill people aged 65 and over: the 65 RCT
Mouncey P, Richards-Belle A, Thomas K, Harrison D, Zia Sadique M, Grieve R, et al.
Health Technol Assess . 2021 Mar; 25(14):1-90. PMID: 33648623
Background: Vasopressors are administered to critical care patients to avoid hypotension, which is associated with myocardial injury, kidney injury and death. However, they work by causing vasoconstriction, which may reduce...
3.
Evaluating the clinical and cost-effectiveness of permissive hypotension in critically ill patients aged 65 years or over with vasodilatory hypotension: Statistical and health economic analysis plan for the 65 trial in article
Thomas K, Patel A, Zia Sadique M, Grieve R, Mason A, Moler S, et al.
J Intensive Care Soc . 2020 Aug; 21(3):230-231. PMID: 32782462
The 65 trial is a pragmatic, multicentre, parallel-group, open-label, randomised clinical trial of permissive hypotension (targeting a mean arterial pressure target of 60-65 mmHg during vasopressor therapy) versus usual care...
4.
A framework for extending trial design to facilitate missing data sensitivity analyses
Mason A, Grieve R, Richards-Belle A, Mouncey P, Harrison D, Carpenter J
BMC Med Res Methodol . 2020 Mar; 20(1):66. PMID: 32183708
Background: Missing data are an inevitable challenge in Randomised Controlled Trials (RCTs), particularly those with Patient Reported Outcome Measures. Methodological guidance suggests that to avoid incorrect conclusions, studies should undertake...
5.
Effect of Reduced Exposure to Vasopressors on 90-Day Mortality in Older Critically Ill Patients With Vasodilatory Hypotension: A Randomized Clinical Trial
Lamontagne F, Richards-Belle A, Thomas K, Harrison D, Zia Sadique M, Grieve R, et al.
JAMA . 2020 Feb; 323(10):938-949. PMID: 32049269
Importance: Vasopressors are commonly administered to intensive care unit (ICU) patients to raise blood pressure. Balancing risks and benefits of vasopressors is a challenge, particularly in older patients. Objective: To...
6.
Effect of a Nurse-Led Preventive Psychological Intervention on Symptoms of Posttraumatic Stress Disorder Among Critically Ill Patients: A Randomized Clinical Trial
Wade D, Mouncey P, Richards-Belle A, Wulff J, Harrison D, Zia Sadique M, et al.
JAMA . 2019 Feb; 321(7):665-675. PMID: 30776295
Importance: A meta-analysis of outcomes during the 6 months after intensive care unit (ICU) discharge indicate a prevalence for clinically important posttraumatic stress disorder (PTSD) symptoms of 25%. Objective: To...
7.
Early, Goal-Directed Therapy for Septic Shock - A Patient-Level Meta-Analysis
Rowan K, Angus D, Bailey M, Barnato A, Bellomo R, Canter R, et al.
N Engl J Med . 2017 Mar; 376(23):2223-2234. PMID: 28320242
Background: After a single-center trial and observational studies suggesting that early, goal-directed therapy (EGDT) reduced mortality from septic shock, three multicenter trials (ProCESS, ARISE, and ProMISe) showed no benefit. This...
8.
A multicentre, randomised controlled trial comparing the clinical effectiveness and cost-effectiveness of early nutritional support via the parenteral versus the enteral route in critically ill patients (CALORIES)
Harvey S, Parrott F, Harrison D, Zia Sadique M, Grieve R, Canter R, et al.
Health Technol Assess . 2016 Apr; 20(28):1-144. PMID: 27089843
Background: Malnutrition is a common problem in critically ill patients in UK NHS critical care units. Early nutritional support is therefore recommended to address deficiencies in nutritional state and related...
9.
Protocolised Management In Sepsis (ProMISe): a multicentre randomised controlled trial of the clinical effectiveness and cost-effectiveness of early, goal-directed, protocolised resuscitation for emerging septic shock
Mouncey P, Osborn T, Sarah Power G, Harrison D, Zia Sadique M, Grieve R, et al.
Health Technol Assess . 2015 Nov; 19(97):i-xxv, 1-150. PMID: 26597979
Background: Early goal-directed therapy (EGDT) is recommended in international guidance for the resuscitation of patients presenting with early septic shock. However, adoption has been limited and uncertainty remains over its...
10.
Trial of early, goal-directed resuscitation for septic shock
Mouncey P, Osborn T, Sarah Power G, Harrison D, Zia Sadique M, Grieve R, et al.
N Engl J Med . 2015 Mar; 372(14):1301-11. PMID: 25776532
Background: Early, goal-directed therapy (EGDT) is recommended in international guidelines for the resuscitation of patients presenting with early septic shock. However, adoption has been limited, and uncertainty about its effectiveness...