Richard A Zager
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Explore the profile of Richard A Zager including associated specialties, affiliations and a list of published articles.
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75
Citations
2141
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Recent Articles
1.
Johnson A, Zager R
Kidney360
. 2025 Mar;
PMID: 40029708
Background: Increased tubular ammoniagenesis is an adaptive response to progressive kidney disease, facilitating net acid excretion. However, excess ammonia production can also exacerbate kidney disease progression, in part, by activating...
2.
Johnson A, Zager R
Physiol Rep
. 2025 Feb;
13(3):e70218.
PMID: 39905680
During systemic stress, syndecan-1 (SDC-1) shedding into plasma results, implying endothelial damage. RBT-1, a "preconditioning" agent, has been shown to mitigate postoperative complications following cardiac surgeries. This study assessed whether...
3.
Zager R
Physiol Rep
. 2022 Oct;
10(20):e15507.
PMID: 36305701
Acute kidney injury (AKI) is a common event, occurring in ~5% and ~35% of hospitalized and ICU patients, respectively. The development of AKI portends an increased risk of morbidity, mortality,...
4.
Zager R, Johnson A
Physiol Rep
. 2022 Jun;
10(12):e15352.
PMID: 35748049
Glutathione-S-transferases (GSTs) are a diverse group of phase II detoxification enzymes which primarily evoke tissue protection via glutathione conjugation to xenobiotics and reactive oxygen species. Given their cytoprotective properties, potential...
5.
Johnson A, Zager R
Transl Res
. 2021 Jul;
237:53-62.
PMID: 34217897
Cardiorenal syndrome I (CRS-1) denotes a state in which acute kidney injury occurs in the setting of acute heart failure (AHF). Isoproterenol (Iso) administration is widly used as an AHF...
6.
Zager R, Johnson A, Therapeutics R
Nephrol Dial Transplant
. 2021 Feb;
36(3):465-474.
PMID: 33547792
Background: Iron sucrose (FeS) administration induces a state of renal preconditioning, protecting against selected forms of acute kidney injury (AKI). Recent evidence suggests that recombinant hepcidin also mitigates acute renal...
7.
Zager R, Johnson A
Physiol Rep
. 2020 Sep;
8(18):e14566.
PMID: 32940965
Background: Tin protoporphyrin (SnPP), a heme oxygenase 1 (HO-1) inhibitor, triggers adaptive tissue responses that confer potent protection against acute renal- and extra-renal tissue injuries. This effect is mediated, in...
8.
Zager R, Johnson A, Guillem A, Keyser J, Singh B
Clin J Am Soc Nephrol
. 2020 Apr;
15(5):633-642.
PMID: 32291269
Background And Objectives: Oxidative stress is a hallmark and mediator of CKD. Diminished antioxidant defenses are thought to be partly responsible. However, there is currently no way to prospectively assess...
9.
Johnson A, Gooley T, Guillem A, Keyser J, Rasmussen H, Singh B, et al.
Am J Physiol Renal Physiol
. 2019 Oct;
317(6):F1563-F1571.
PMID: 31608670
Experimental data suggest that iron sucrose (FeS) injection, used either alone or in combination with other prooxidants, can induce "renal preconditioning," in part by upregulating cytoprotective ferritin levels. However, the...
10.
Acute kidney injury induces dramatic p21 upregulation via a novel, glucocorticoid-activated, pathway
Zager R, Johnson A
Am J Physiol Renal Physiol
. 2019 Jan;
316(4):F674-F681.
PMID: 30698046
The cyclin kinase inhibitor p21 is acutely upregulated during acute kidney injury (AKI) and exerts cytoprotective effects. A proposed mechanism is oxidant stress-induced activation of p53, the dominant p21 transcription...