Ali C M Johnson
Overview
Explore the profile of Ali C M Johnson including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
44
Citations
1227
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Johnson A, Zager R
Kidney360
. 2025 Mar;
PMID: 40029708
Background: Increased tubular ammoniagenesis is an adaptive response to progressive kidney disease, facilitating net acid excretion. However, excess ammonia production can also exacerbate kidney disease progression, in part, by activating...
2.
Johnson A, Zager R
Physiol Rep
. 2025 Feb;
13(3):e70218.
PMID: 39905680
During systemic stress, syndecan-1 (SDC-1) shedding into plasma results, implying endothelial damage. RBT-1, a "preconditioning" agent, has been shown to mitigate postoperative complications following cardiac surgeries. This study assessed whether...
3.
Zager R, Johnson A
Physiol Rep
. 2022 Jun;
10(12):e15352.
PMID: 35748049
Glutathione-S-transferases (GSTs) are a diverse group of phase II detoxification enzymes which primarily evoke tissue protection via glutathione conjugation to xenobiotics and reactive oxygen species. Given their cytoprotective properties, potential...
4.
Zager R, Johnson A, Therapeutics R
Nephrol Dial Transplant
. 2021 Feb;
36(3):465-474.
PMID: 33547792
Background: Iron sucrose (FeS) administration induces a state of renal preconditioning, protecting against selected forms of acute kidney injury (AKI). Recent evidence suggests that recombinant hepcidin also mitigates acute renal...
5.
Zager R, Johnson A
Physiol Rep
. 2020 Sep;
8(18):e14566.
PMID: 32940965
Background: Tin protoporphyrin (SnPP), a heme oxygenase 1 (HO-1) inhibitor, triggers adaptive tissue responses that confer potent protection against acute renal- and extra-renal tissue injuries. This effect is mediated, in...
6.
Zager R, Johnson A, Guillem A, Keyser J, Singh B
Clin J Am Soc Nephrol
. 2020 Apr;
15(5):633-642.
PMID: 32291269
Background And Objectives: Oxidative stress is a hallmark and mediator of CKD. Diminished antioxidant defenses are thought to be partly responsible. However, there is currently no way to prospectively assess...
7.
Acute kidney injury induces dramatic p21 upregulation via a novel, glucocorticoid-activated, pathway
Zager R, Johnson A
Am J Physiol Renal Physiol
. 2019 Jan;
316(4):F674-F681.
PMID: 30698046
The cyclin kinase inhibitor p21 is acutely upregulated during acute kidney injury (AKI) and exerts cytoprotective effects. A proposed mechanism is oxidant stress-induced activation of p53, the dominant p21 transcription...
8.
Johnson A, Zager R
J Am Soc Nephrol
. 2018 Jul;
29(8):2157-2167.
PMID: 29980651
Background: Recent clinical data support the utility/superiority of a new AKI biomarker ("NephroCheck"), the arithmetic product of urinary TIMP × IGFBP7 concentrations. However, the pathophysiologic basis for its utility remains...
9.
Johnson A, Zager R
Nephrol Dial Transplant
. 2018 Mar;
33(11):1927-1941.
PMID: 29522116
Background: P21, a cyclin kinase inhibitor, is upregulated by renal 'ischemic preconditioning' (IPC), and induces a 'cytoresistant' state. However, P21-induced cell cycle inhibition can also contribute to cellular senescence, a...
10.
Johnson A, Delrow J, Zager R
Transl Res
. 2017 Jun;
186:1-18.
PMID: 28586635
Tin protoporphyrin (SnPP), a heme oxygenase (HO) inhibitor, can paradoxically protect against diverse forms of acute kidney injury (AKI). This study sought potential underlying mechanisms. CD-1 mice received intravenous SnPP,...