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Richard A Lindberg

Explore the profile of Richard A Lindberg including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 840
Followers 0
Related Specialties
Endocrinology
Pharmacology
Physiology
Top 10 Co-Authors
Murielle M Veniant
Wei Gu
Katherine A Winters
Renee Komorowski
Hai Yan
David J Lloyd
Glenn Sivits
Melissa Graham
Yue-Sheng Li
Jie Yang
Published In
J Pharmacol Exp Ther
Diabetes
Am J Physiol Endocrinol Metab
Affiliations
Soon will be listed here.
Recent Articles
1.
Pharmacological targeting of glucagon and glucagon-like peptide 1 receptors has different effects on energy state and glucose homeostasis in diet-induced obese mice
Gu W, Lloyd D, Chinookswong N, Komorowski R, Sivits Jr G, Graham M, et al.
J Pharmacol Exp Ther . 2011 Apr; 338(1):70-81. PMID: 21471191
Pharmacologic contributions of directly agonizing glucagon-like peptide 1 (GLP-1) receptor or antagonizing glucagon receptor (GCGR) on energy state and glucose homeostasis were assessed in diet-induced obese (DIO) mice. Metabolic rate...
2.
Glucagon receptor antagonist-mediated improvements in glycemic control are dependent on functional pancreatic GLP-1 receptor
Gu W, Winters K, Motani A, Komorowski R, Zhang Y, Liu Q, et al.
Am J Physiol Endocrinol Metab . 2010 Jul; 299(4):E624-32. PMID: 20647556
Antagonism of the glucagon receptor (GCGR) is associated with increased circulating levels of glucagon-like peptide-1 (GLP-1). To investigate the contribution of GLP-1 to the antidiabetic actions of GCGR antagonism, we...
3.
Long-term inhibition of the glucagon receptor with a monoclonal antibody in mice causes sustained improvement in glycemic control, with reversible alpha-cell hyperplasia and hyperglucagonemia
Gu W, Yan H, Winters K, Komorowski R, Vonderfecht S, Atangan L, et al.
J Pharmacol Exp Ther . 2009 Sep; 331(3):871-81. PMID: 19720878
Uncontrolled hepatic glucose output (HGO) contributes significantly to the pathological hyperglycemic state of patients with type 2 diabetes. Glucagon, through action on its receptor, stimulates HGO, thereby leading to increased...
4.
Fully human monoclonal antibodies antagonizing the glucagon receptor improve glucose homeostasis in mice and monkeys
Yan H, Gu W, Yang J, Bi V, Shen Y, Lee E, et al.
J Pharmacol Exp Ther . 2009 Jan; 329(1):102-11. PMID: 19129372
Antagonizing the glucagon signaling pathway represents an attractive therapeutic approach for reducing excess hepatic glucose production in patients with type 2 diabetes. Despite extensive efforts, there is currently no human...
5.
Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice
Xu J, Lloyd D, Hale C, Stanislaus S, Chen M, Sivits G, et al.
Diabetes . 2008 Oct; 58(1):250-9. PMID: 18840786
Objective: Fibroblast growth factor 21 (FGF21) has emerged as an important metabolic regulator of glucose and lipid metabolism. The aims of the current study are to evaluate the role of...
6.
Generation and characterization of two novel mouse models exhibiting the phenotypes of the metabolic syndrome: Apob48-/-Lepob/ob mice devoid of ApoE or Ldlr
Lloyd D, McCormick J, Helmering J, Kim K, Wang M, Fordstrom P, et al.
Am J Physiol Endocrinol Metab . 2007 Dec; 294(3):E496-505. PMID: 18160459
The metabolic syndrome is a group of disorders including obesity, insulin resistance, atherogenic dyslipidemia, hyperglycemia, and hypertension. To date, few animal models have been described to recapitulate the phenotypes of...
7.
Targeting foxo1 in mice using antisense oligonucleotide improves hepatic and peripheral insulin action
Samuel V, Choi C, Phillips T, Romanelli A, Geisler J, Bhanot S, et al.
Diabetes . 2006 Jun; 55(7):2042-50. PMID: 16804074
Fasting hyperglycemia, a prominent finding in diabetes, is primarily due to increased gluconeogenesis. The transcription factor Foxo1 links insulin signaling to decreased transcription of PEPCK and glucose-6-phosphatase (G6Pase) and provides...