Richard A Heyman
Overview
Explore the profile of Richard A Heyman including associated specialties, affiliations and a list of published articles.
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21
Citations
2152
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Recent Articles
1.
Joseph J, Darimont B, Zhou W, Arrazate A, Young A, Ingalla E, et al.
Elife
. 2019 Jan;
8.
PMID: 30614786
No abstract available.
2.
Joseph J, Darimont B, Zhou W, Arrazate A, Young A, Ingalla E, et al.
Elife
. 2016 Jul;
5.
PMID: 27410477
ER-targeted therapeutics provide valuable treatment options for patients with ER+ breast cancer, however, current relapse and mortality rates emphasize the need for improved therapeutic strategies. The recent discovery of prevalent...
3.
Clegg N, Wongvipat J, Joseph J, Tran C, Ouk S, Dilhas A, et al.
Cancer Res
. 2012 Jan;
72(6):1494-503.
PMID: 22266222
Continued reliance on the androgen receptor (AR) is now understood as a core mechanism in castration-resistant prostate cancer (CRPC), the most advanced form of this disease. While established and novel...
4.
Herbert M, Siegel D, Staszewski L, Cayanan C, Banerjee U, Dhamija S, et al.
Bioorg Med Chem Lett
. 2010 Aug;
20(19):5718-21.
PMID: 20801037
Optimization of a screening hit from uHTS led to the discovery of TGR5 agonist 32, which was shown to have activity in a rodent model for diabetes.
5.
Leibowitz M, Ardecky R, Boehm M, Broderick C, Carfagna M, Crombie D, et al.
Endocrinology
. 2005 Nov;
147(2):1044-53.
PMID: 16269450
Specific retinoid X receptor (RXR) agonists, such as LG100268 (LG268), and the thiazolidinedione (TZD) PPARgamma agonists, such as rosiglitazone, produce insulin sensitization in rodent models of insulin resistance and type...
6.
Westin S, Heyman R, Martin R
Mini Rev Med Chem
. 2005 Aug;
5(8):719-27.
PMID: 16101408
The farnesoid X receptor (FXR) is a nuclear receptor expressed in tissues exposed to high concentrations of bile acids such as the liver, kidney and intestine and functions as a...
7.
Levin N, Bischoff E, Daige C, Thomas D, Vu C, Heyman R, et al.
Arterioscler Thromb Vasc Biol
. 2004 Nov;
25(1):135-42.
PMID: 15539622
Objective: Complications of atherosclerotic cardiovascular disease due to elevated blood cholesterol levels are the major cause of death in the Western world. The liver X receptors, LXRalpha and LXRbeta (LXRs),...
8.
Willy P, Murray I, Qian J, Busch B, Stevens Jr W, Martin R, et al.
Proc Natl Acad Sci U S A
. 2004 Jun;
101(24):8912-7.
PMID: 15184675
Peroxisome proliferator-activated receptor gamma (PPARgamma) coactivator 1alpha (PGC-1alpha) is a transcriptional coactivator that is a key component in the regulation of energy production and utilization in metabolic tissues. Recent work...
9.
Schulman I, Heyman R
Chem Biol
. 2004 May;
11(5):639-46.
PMID: 15157874
Members of the nuclear hormone receptor superfamily function as ligand-activated transcription factors to regulate genetic networks controlling cell growth and differentiation, inflammatory responses, and metabolism. The ability to modulate nuclear...
10.
Rendi M, Suh N, Lamph W, Krajewski S, Reed J, Heyman R, et al.
Cancer Res
. 2004 May;
64(10):3566-71.
PMID: 15150113
We show that the selective estrogen receptor modulator arzoxifene (Arz) and the rexinoid LG100268 (268) synergize to promote apoptosis in a rat model of estrogen receptor-positive breast carcinoma and in...