Ricardo B R Azevedo
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Explore the profile of Ricardo B R Azevedo including associated specialties, affiliations and a list of published articles.
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31
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746
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Recent Articles
1.
Kalirad A, Burch C, Azevedo R
PLoS Genet
. 2024 Jan;
20(1):e1011126.
PMID: 38252672
Dobzhansky and Muller proposed a general mechanism through which microevolution, the substitution of alleles within populations, can cause the evolution of reproductive isolation between populations and, therefore, macroevolution. As allopatric...
2.
Olofsson P, Chipkin L, Daileda R, Azevedo R
J Math Biol
. 2023 Nov;
87(6):88.
PMID: 37994999
Asexual populations are expected to accumulate deleterious mutations through a process known as Muller's ratchet. Lynch and colleagues proposed that the ratchet eventually results in a vicious cycle of mutation...
3.
Tarkington J, Zhang H, Azevedo R, Zufall R
Evolution
. 2023 Jan;
77(1):36-48.
PMID: 36622280
Understanding the mechanisms that generate genetic variation, and thus contribute to the process of adaptation, is a major goal of evolutionary biology. Mutation and genetic exchange have been well studied...
4.
Azevedo R, Olofsson P
Math Biosci
. 2021 Sep;
341:108708.
PMID: 34560091
Evolutionary rescue is the process whereby a declining population may start growing again, thus avoiding extinction, via an increase in the frequency of fitter genotypes. These genotypes may either already...
5.
Karkare K, Lai H, Azevedo R, Cooper T
Mol Biol Evol
. 2021 Mar;
38(7):2869-2879.
PMID: 33744956
Populations of Escherichia coli selected in constant and fluctuating environments containing lactose often adapt by substituting mutations in the lacI repressor that cause constitutive expression of the lac operon. These...
6.
Whitlock A, Azevedo R, Burch C
Evolution
. 2019 Apr;
73(6):1089-1100.
PMID: 30997680
We build on previous observations that Hill-Robertson interference generates an advantage of sex that, in structured populations, can be large enough to explain the evolutionary maintenance of costly sex. We...
7.
Kelleher E, Azevedo R, Zheng Y
Genome Biol Evol
. 2018 Sep;
10(11):3038-3057.
PMID: 30252073
Transposable elements (TEs) are genomic parasites that impose fitness costs on their hosts by producing deleterious mutations and disrupting gametogenesis. Host genomes avoid these costs by regulating TE activity, particularly...
8.
Zheng Y, Graur D, Azevedo R
J Mol Evol
. 2018 Jun;
86(6):365-378.
PMID: 29955898
A low ratio of nonsynonymous and synonymous substitution rates (dN/dS) at a codon is an indicator of functional constraint caused by purifying selection. Intuitively, the functional constraint would also be...
9.
Suarez-Villagran M, Azevedo R, Miller Jr J
Genome Biol Evol
. 2018 Apr;
10(4):1039-1047.
PMID: 29617801
Biases in mutation rate can influence molecular evolution, yielding rates of evolution that vary widely in different parts of the genome and even among neighboring nucleotides. Here, we explore one...
10.
Winter D, Wu S, Howell A, Azevedo R, Zufall R, Cartwright R
Bioinformatics
. 2018 Mar;
34(15):2659-2660.
PMID: 29566129
Summary: Mutation accumulation (MA) is the most widely used method for directly studying the effects of mutation. By sequencing whole genomes from MA lines, researchers can directly study the rate...