Ricardo A Gomes
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Explore the profile of Ricardo A Gomes including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
377
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Recent Articles
1.
Ferreira I, Torrejon E, Abecasis B, Alexandre B, Gomes R, Verslype C, et al.
SLAS Discov
. 2024 Mar;
29(3):100154.
PMID: 38521503
Sorafenib is a multikinase inhibitor indicated for first-line treatment of unresectable hepatocellular carcinoma. Despite its widespread use in the clinic, the existing knowledge of sorafenib mode-of-action remains incomplete. To build...
2.
Carvalho S, Profit L, Krishnan S, Gomes R, Alexandre B, Clavier S, et al.
J Biotechnol
. 2024 Feb;
384:1-11.
PMID: 38340900
Host cell proteins (HCPs) are process-related impurities expressed by the host cells during biotherapeutics' manufacturing, such as monoclonal antibodies (mAbs). Some challenging HCPs evade clearance during the downstream processing and...
3.
Chegao A, Guarda M, Alexandre B, Shvachiy L, Temido-Ferreira M, Marques-Morgado I, et al.
NPJ Parkinsons Dis
. 2022 Apr;
8(1):51.
PMID: 35468899
Alpha-synuclein (aSyn) is a central player in the pathogenesis of synucleinopathies due to its accumulation in typical protein aggregates in the brain. However, it is still unclear how it contributes...
4.
Fernandes B, Castro R, Bhoelan F, Bemelman D, Gomes R, Costa J, et al.
Pharmaceutics
. 2022 Apr;
14(4).
PMID: 35456687
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) homotrimeric spike (S) protein is responsible for mediating host cell entry by binding to the angiotensin-converting enzyme 2 (ACE2) receptor, thus being...
5.
Carvalho S, Gomes R, Pfenninger A, Fischer M, Strotbek M, Isidro I, et al.
PLoS One
. 2022 Jan;
17(1):e0262711.
PMID: 35085302
Quality control of biopharmaceuticals such as monoclonal antibodies (mAbs) has been evolving and becoming more challenging as the requirements of the regulatory agencies increase due to the demanding complexity of...
6.
Costa J, Gromicho M, Pronto-Laborinho A, Almeida C, Gomes R, Guerreiro A, et al.
Diagnostics (Basel)
. 2021 Aug;
11(7).
PMID: 34359293
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative neuromuscular disease that affects motor neurons controlling voluntary muscles. Survival is usually 2-5 years after onset, and death occurs due to respiratory failure....
7.
Castro R, Nobre L, Eleuterio R, Thomaz M, Pires A, Monteiro S, et al.
Biotechnol Bioeng
. 2021 Feb;
118(6):2202-2219.
PMID: 33624859
Serological assays are valuable tools to study SARS-CoV-2 spread and, importantly, to identify individuals that were already infected and would be potentially immune to a virus reinfection. SARS-CoV-2 Spike protein...
8.
Erny G, Gomes R, Santos M, Santos L, Neuparth N, Carreiro-Martins P, et al.
ACS Omega
. 2020 Jul;
5(26):16089-16098.
PMID: 32656431
Separation techniques hyphenated to high-resolution mass spectrometry are essential in untargeted metabolomic analyses. Due to the complexity and size of the resulting data, analysts rely on computer-assisted tools to mine...
9.
Gomes R, Almeida C, Correia C, Guerreiro A, Simplicio A, Abreu I, et al.
PLoS One
. 2019 Jul;
14(7):e0219156.
PMID: 31291294
The biopharmaceutical industry is growing at a fast pace, making nowadays 20% of the pharma market. Within this market, therapeutic monoclonal antibodies (mAbs) are the dominant product class. With the...
10.
Cunha B, Aguiar T, Carvalho S, Silva M, Gomes R, Carrondo M, et al.
J Biotechnol
. 2017 Feb;
248:87-98.
PMID: 28174039
To deliver the required cell numbers and doses to therapy, scaling-up production and purification processes (at least to the liter-scale) while maintaining cells' characteristics is compulsory. Therefore, the aim of...