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Reymundo Dominguez

Explore the profile of Reymundo Dominguez including associated specialties, affiliations and a list of published articles. Areas
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Articles 13
Citations 297
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Dominguez R, Zitting M, Liu Q, Patel A, Babadjouni R, Hodis D, et al.
J Stroke Cerebrovasc Dis . 2018 Apr; 27(7):1743-1751. PMID: 29602614
Background And Purpose: Estradiol is a sex steroid hormone known to protect the brain against damage related to transient and global cerebral ischemia. In the present study, we leverage an...
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Dueck H, Ai R, Camarena A, Ding B, Dominguez R, Evgrafov O, et al.
BMC Genomics . 2016 Nov; 17(1):966. PMID: 27881084
Background: Recently, measurement of RNA at single cell resolution has yielded surprising insights. Methods for single-cell RNA sequencing (scRNA-seq) have received considerable attention, but the broad reliability of single cell...
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Kisler K, Dominguez R
Methods Mol Biol . 2015 Nov; 1366:175-187. PMID: 26585135
Trafficking studies of plasma membrane-localized intracellular estrogen receptors have mainly relied on biochemical and histological techniques to locate the receptor before and after estradiol stimulation. More often than not these...
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Kisler K, Chow R, Dominguez R
J Steroids Horm Sci . 2013 Dec; Suppl 12. PMID: 24353903
Estradiol is a steroid hormone that binds and activates estradiol receptors. Activation of these receptors is known to modulate neuronal physiology and provide neuroprotection, but it is not completely understood...
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Dominguez R, Dewing P, Kuo J, Micevych P
Steroids . 2013 Jan; 78(6):607-13. PMID: 23296142
Regulation of sexual reproduction by estradiol involves the activation of estrogen receptors (ERs) in the hypothalamus. Of the two classical ERs involved in reproduction, ERα appears to be the critical...
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Dominguez R, Micevych P
J Neurosci . 2010 Sep; 30(38):12589-96. PMID: 20861365
Estrogen receptors (ERs) and estrogen-binding proteins have been localized intracellularly and on the cell surface. The membrane-associated proteins initiate signaling that activates a myriad of cellular responses including the modulation...
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Micevych P, Dominguez R
Front Neuroendocrinol . 2009 May; 30(3):315-27. PMID: 19416735
While the physiology of membrane-initiated estradiol signaling in the nervous system has remained elusive, a great deal of progress has been made toward understanding the activation of cell signaling. Membrane-initiated...
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Dominguez R, Hu E, Zhou M, Baudry M
J Neurosci . 2009 Apr; 29(13):4228-38. PMID: 19339617
17-beta-Estradiol (E2) is a steroid hormone involved in numerous bodily functions, including several brain functions. In particular, E2 is neuroprotective against excitotoxicity and other forms of brain injuries, a property...
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Zhou M, Dominguez R, Baudry M
J Neurochem . 2007 Sep; 103(6):2212-23. PMID: 17868299
Although oxygen/glucose deprivation (OGD) has been widely used as a model of ischemic brain damage, the mechanisms underlying acute neuronal death in this model are not yet well understood. We...