Renee C Ryals
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Explore the profile of Renee C Ryals including associated specialties, affiliations and a list of published articles.
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23
Citations
645
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Recent Articles
1.
Vasudevan A, Jozic A, Curtis A, Bodi E, Ryals R, Sahay G
J Control Release
. 2025 Jan;
379:1022-1028.
PMID: 39875072
Lipid nanoparticles (LNPs) have shown great potential in the field of gene therapy for retinal diseases. To expand on this application, we investigated LNP-mediated mRNA delivery to the anterior chamber...
2.
Babcock S, Curtis A, Gaston G, Elizondo G, Gillingham M, Ryals R
Invest Ophthalmol Vis Sci
. 2024 Jun;
65(6):33.
PMID: 38904639
Purpose: Recent studies have shown that the retinal pigment epithelium (RPE) relies on fatty acid oxidation (FAO) for energy, however, its role in overall retinal health is unknown. The only...
3.
Eygeris Y, Henderson M, Curtis A, Jozic A, Stoddard J, Reynaga R, et al.
Small
. 2024 May;
20(37):e2400815.
PMID: 38738752
Complete encapsulation of nucleic acids by lipid-based nanoparticles (LNPs) is often thought to be one of the main prerequisites for successful nucleic acid delivery, as the lipid environment protects mRNA...
4.
Eygeris Y, Gupta M, Kim J, Jozic A, Gautam M, Renner J, et al.
Proc Natl Acad Sci U S A
. 2024 Mar;
121(11):e2307813120.
PMID: 38437570
Lipid nanoparticles (LNPs) largely rely on ionizable lipids to yield successful nucleic acid delivery via electrostatic disruption of the endosomal membrane. Here, we report the identification and evaluation of ionizable...
5.
Kim J, Eygeris Y, Ryals R, Jozic A, Sahay G
Nat Nanotechnol
. 2023 Dec;
19(4):428-447.
PMID: 38151642
In recent years, nanoparticles have evolved to a clinical modality to deliver diverse nucleic acids. Rising interest in nanomedicines comes from proven safety and efficacy profiles established by continuous efforts...
6.
Gautam M, Jozic A, Su G, Herrera-Barrera M, Curtis A, Arrizabalaga S, et al.
Nat Commun
. 2023 Oct;
14(1):6468.
PMID: 37833442
Ocular delivery of lipid nanoparticle (LNPs) packaged mRNA can enable efficient gene delivery and editing. We generated LNP variants through the inclusion of positively charged-amine-modified polyethylene glycol (PEG)-lipids (LNPa), negatively...
7.
Vartanian V, Krey J, Chatterjee P, Curtis A, Six M, Rice S, et al.
Genes Brain Behav
. 2023 Jun;
22(4):e12849.
PMID: 37328946
Relationships between novel phenotypic behaviors and specific genetic alterations are often discovered using target-specific, directed mutagenesis or phenotypic selection following chemical mutagenesis. An alternative approach is to exploit deficiencies in...
8.
Herrera-Barrera M, Ryals R, Gautam M, Jozic A, Landry M, Korzun T, et al.
Sci Adv
. 2023 Jan;
9(2):eadd4623.
PMID: 36630502
Lipid nanoparticle (LNP)-based mRNA delivery holds promise for the treatment of inherited retinal degenerations. Currently, LNP-mediated mRNA delivery is restricted to the retinal pigment epithelium (RPE) and Müller glia. LNPs...
9.
Surendran H, Soundararajan L, Reddy K V, Subramani J, Stoddard J, Reynaga R, et al.
STAR Protoc
. 2022 Nov;
3(4):101803.
PMID: 36386870
We present an optimized protocol for guided differentiation of retinal pigment epithelium (RPE) cells from human-induced pluripotent stem cells (iPSC). De novo-generated RPE cells are mature, polarized, and mimic the...
10.
Ryals R, Patel S, Acosta C, McKinney M, Pennesi M, Sahay G
PLoS One
. 2020 Oct;
15(10):e0241006.
PMID: 33119640
Gene therapy is now an effective approach to treat many forms of retinal degeneration. Delivery agents that are cell-specific, allow for multiple dosing regimens, and have low immunogenicity are needed...