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Rene Pool

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Articles 74
Citations 2183
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Recent Articles
1.
Azcona-Granada N, Geijsen A, Pool R, Pelt D, Bartels M
Sci Rep . 2025 Feb; 15(1):6997. PMID: 40016293
The biological complexity of wellbeing is studied from various perspectives, including genetics and epigenetics. However, there is a knowledge gap concerning other layers, such as metabolomics, which is dynamic and...
2.
Van Asselt A, Pool R, Hottenga J, Beck J, Finnicum C, Johnson B, et al.
Biomolecules . 2025 Feb; 15(2). PMID: 40001554
Asthma, a chronic respiratory condition characterized by airway inflammation, affects millions of individuals worldwide. Challenges remain in asthma prediction and diagnosis from its complex etiology involving genetic and environmental factors....
3.
Singh M, Dolan C, Lapato D, Hottenga J, Pool R, Verhulst B, et al.
Eur J Epidemiol . 2025 Jan; 40(1):55-69. PMID: 39786687
Cigarette smoking is associated with numerous differentially-methylated genomic loci in multiple human tissues. These associations are often assumed to reflect the causal effects of smoking on DNA methylation (DNAm), which...
4.
Hubers N, Drouard G, Jansen R, Pool R, Hottenga J, Ollikainen M, et al.
Am J Med Genet A . 2024 Dec; 197(4):e63971. PMID: 39676692
Monozygotic (MZ) and dizygotic (DZ) twins are studied to understand genetic and environmental influences on complex traits, however the mechanisms behind twinning are not completely understood. (Epi)genomic studies identified SNPs...
5.
Van Asselt A, Beck J, Finnicum C, Johnson B, Kallsen N, Viet S, et al.
Clin Epigenetics . 2024 Nov; 16(1):151. PMID: 39488688
Background: Asthma, a complex respiratory disease, presents with inflammatory symptoms in the lungs, blood, and other tissues. We investigated the relationship between DNA methylation and 35 clinical markers of asthma....
6.
Pelt D, Habets P, Vinkers C, Ligthart L, van Beijsterveldt C, Pool R, et al.
Nat Ment Health . 2024 Oct; 2(10):1217-1230. PMID: 39464304
Effective personalized well-being interventions require the ability to predict who will thrive or not, and the understanding of underlying mechanisms. Here, using longitudinal data of a large population cohort (the...
7.
Hubers N, Page C, Ligthart L, Pool R, Hottenga J, Dongen J, et al.
Twin Res Hum Genet . 2024 Sep; :1-7. PMID: 39239778
Previous studies have shown that mothers of naturally conceived dizygotic (DZ) twins tend to be taller, older, and smoke more than mothers of naturally conceived monozygotic (MZ) twin and mothers...
8.
Bizzarri D, Reinders M, Kuiper L, Beekman M, Deelen J, van Meurs J, et al.
EBioMedicine . 2024 Aug; 107:105279. PMID: 39154540
Background: H-NMR metabolomics and DNA methylation in blood are widely known biomarkers predicting age-related physiological decline and mortality yet exert mutually independent mortality and frailty signals. Methods: Leveraging multi-omics data...
9.
Van Asselt A, Beck J, Johnson B, Finnicum C, Kallsen N, Viet S, et al.
medRxiv . 2024 Aug; PMID: 39108502
Background: Asthma, a complex respiratory disease, presents with inflammatory symptoms in the lungs, blood, and other tissues. We investigated the relationship between DNA methylation and 35 clinical markers of asthma....
10.
Singh M, Dolan C, Lapato D, Hottenga J, Pool R, Verhulst B, et al.
medRxiv . 2024 Jul; PMID: 38946972
Cigarette smoking is associated with numerous differentially-methylated genomic loci in multiple human tissues. These associations are often assumed to reflect the causal effects of smoking on DNA methylation (DNAm), which...