Rene E Harrison
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Explore the profile of Rene E Harrison including associated specialties, affiliations and a list of published articles.
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42
Citations
1382
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Recent Articles
1.
Fiorino C, Omer S, Gandhi N, Harrison R
Bio Protoc
. 2025 Jan;
15(1):e5155.
PMID: 39803321
The bone is a highly dynamic organ that undergoes continuous remodeling through an intricate balance of bone formation and degradation. Hyperactivation of the bone-degrading cells, the osteoclasts (OCs), occurs in...
2.
Gandhi N, Omer S, Harrison R
Int J Mol Sci
. 2024 Jun;
25(11).
PMID: 38892322
Estrogen (17β-estradiol) deficiency post-menopause alters bone homeostasis whereby bone resorption by osteoclasts exceeds bone formation by osteoblasts, leading to osteoporosis in females. We established an in vitro model to examine...
3.
Omer S, Li J, Yang C, Harrison R
Mol Biol Cell
. 2023 Dec;
35(3):ar26.
PMID: 38117588
Phagocytosis by macrophages is a highly polarized process to destroy large target cells. Binding to particles induces extensive cortical actin-generated forces that drive the formation of elaborate pseudopods around the...
4.
Fu Y, Macwan V, Heineman R, Terebiznik M, Harrison R
Pathogens
. 2022 Aug;
11(8).
PMID: 36015029
is an accidental pathogen that replicates intracellularly within the -containing vacuole (LCV) in macrophages. Within an hour of infection, secretes effectors to manipulate Rab1 and intercept ER-derived vesicles to the...
5.
Philip R, Fiorino C, Harrison R
Mol Biol Cell
. 2022 May;
33(8):ar68.
PMID: 35511803
Osteoclasts are highly specialized, multinucleated cells responsible for the selective resorption of the dense, calcified bone matrix. Microtubules (MTs) contribute to the polarization and trafficking events involved in bone resorption...
6.
Fu Y, Harrison R
Front Immunol
. 2021 May;
12:662063.
PMID: 33995386
Phagocytosis is an essential process for the uptake of large (>0.5 µm) particulate matter including microbes and dying cells. Specialized cells in the body perform phagocytosis which is enabled by...
7.
Poirier M, Fiorino C, Rajasekar T, Harrison R
J Cell Sci
. 2020 Jun;
133(12).
PMID: 32501286
The mechanism and role of transient F-actin recruitment, or F-actin 'flashes', on phagosomes remains enigmatic. Here we provide a comprehensive characterization of F-actin flashing dynamics on phagosomes, including receptor and...
8.
Fournier R, Harrison R
Connect Tissue Res
. 2020 May;
62(4):436-453.
PMID: 32375524
: The rotary cell culture system (RCCS) is a common clinorotation device for cell culture. It is also used as a low-shear suspension culture bioreactor to form functionalized 3D tissue...
9.
Acharya D, Li X, Heineman R, Harrison R
Front Immunol
. 2020 Jan;
10:3049.
PMID: 31993058
Macrophages are professional phagocytes that are uniquely situated between the innate and adaptive arms of immunity with a high capacity for phagocytosis and proinflammatory cytokine production as well as antigen...
10.
Naik U, Nguyen Q, Harrison R
J Cell Biochem
. 2019 Jun;
121(1):183-199.
PMID: 31172552
Our current understanding of phagocytosis is largely derived from studies of individual receptor-ligand interactions and their downstream signaling pathways. Because phagocytes are exposed to a variety of ligands on heterogeneous...