Renato Paro
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Explore the profile of Renato Paro including associated specialties, affiliations and a list of published articles.
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75
Citations
3709
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Recent Articles
1.
Haellman V, Pirkl M, Akmammedov A, Saxena P, Beerenwinkel N, Paro R, et al.
Metab Eng
. 2022 Jun;
73:70-81.
PMID: 35724832
CRISPR-based systems have fundamentally transformed our ability to study and manipulate stem cells. We explored the possibility of using catalytically dead Cas9 (dCas9) from S. pyogenes as a platform for...
2.
Geigges M, Gubser P, Unterstab G, Lecoultre Y, Paro R, Hess C
Sci Rep
. 2020 Jun;
10(1):9411.
PMID: 32523060
Reverse-transcription quantitative real-time polymerase chain reaction (RT-qPCR) is widely used for mRNA quantification. To accurately measure changing gene transcript levels under different experimental conditions, the use of appropriate reference gene...
3.
Geigges M, Arekatla G, Paro R
PLoS One
. 2020 Apr;
15(4):e0231498.
PMID: 32287290
The Polycomb group (PcG) proteins are chromatin factors underlying the process of transcriptional memory to preserve developmental decisions and keep cellular identities. However, not only developmental signals need to be...
4.
Brykczynska U, Geigges M, Wiedemann S, Dror E, Boni-Schnetzler M, Hess C, et al.
Cell Rep
. 2020 Feb;
30(5):1627-1643.e7.
PMID: 32023474
The innate immune system safeguards the organism from both pathogenic and environmental stressors. Also, physiologic levels of nutrients affect organismal and intra-cellular metabolism and challenge the immune system. In the...
5.
Akmammedov A, Geigges M, Paro R
Fly (Austin)
. 2019 May;
13(1-4):42-50.
PMID: 31094269
Polycomb group (PcG) and Trithorax group (TrxG) proteins orchestrate development of a multicellular organism by faithfully maintaining cell fate decisions made early in embryogenesis. An important chromatin mark connected to...
6.
Jiang Y, Seimiya M, Schlumpf T, Paro R
Nat Commun
. 2018 Aug;
9(1):3293.
PMID: 30120247
Polycomb group proteins are epigenetic regulators maintaining transcriptional memory during cellular proliferation. In Drosophila larvae, malfunction of Polyhomeotic (Ph), a member of the PRC1 silencing complex, results in neoplastic growth....
7.
Torres J, Monti R, Moore A, Seimiya M, Jiang Y, Beerenwinkel N, et al.
Elife
. 2018 Mar;
7.
PMID: 29560857
Tumor initiation is often linked to a loss of cellular identity. Transcriptional programs determining cellular identity are preserved by epigenetically-acting chromatin factors. Although such regulators are among the most frequently...
8.
Beira J, Torres J, Paro R
PLoS Genet
. 2018 Jan;
14(1):e1007187.
PMID: 29357360
In response to stress and injury a coordinated activation of conserved signalling modules, such as JNK and JAK/STAT, is critical to trigger regenerative tissue restoration. While these pathways rebuild homeostasis...
9.
Pereira A, Paro R
Epigenetics Chromatin
. 2017 Dec;
10(1):57.
PMID: 29208012
Background: Numerous target genes of the Polycomb group (PcG) are transiently activated by a stimulus and subsequently repressed. However, mechanisms by which PcG proteins regulate such target genes remain elusive....
10.
Akmammedov A, Geigges M, Paro R
Sci Rep
. 2017 Aug;
7(1):6899.
PMID: 28761084
An ideal transgenic gene expression system is inducible, non-leaky, and well tolerated by the target organism. While the former has been satisfactorily realized, leakiness and heavy physiological burden imposed by...