Reinhard Grausenburger
Overview
Explore the profile of Reinhard Grausenburger including associated specialties, affiliations and a list of published articles.
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25
Citations
850
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0
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Recent Articles
1.
Gutmann M, Ertl I, Herek P, Vician P, Pirker C, Nossing C, et al.
Eur Urol Oncol
. 2024 May;
7(6):1166-1170.
PMID: 38755094
Current standard-of-care systemic therapy options for locally advanced and metastatic bladder cancer (BC), which are predominantly based on cisplatin-gemcitabine combinations, are limited by significant treatment failure rates and frailty-based patient...
2.
Mayer I, Doma E, Klampfl T, Prchal-Murphy M, Kollmann S, Schirripa A, et al.
Blood
. 2024 Apr;
144(2):156-170.
PMID: 38684032
Hematopoietic stem cells (HSCs) are characterized by the ability to self-renew and to replenish the hematopoietic system. The cell-cycle kinase cyclin-dependent kinase 6 (CDK6) regulates transcription, whereby it has both...
3.
Grausenburger R, Herek P, Shariat S, Englinger B
Curr Opin Urol
. 2024 Apr;
34(4):236-243.
PMID: 38650456
Purpose Of Review: Current risk stratification and treatment decision-making for bladder cancer informed by histopathology as well as molecular diagnostics face limitations. This review summarizes recent advancements in single-cell and...
4.
Klein K, Kollmann S, Hiesinger A, List J, Kendler J, Klampfl T, et al.
Blood
. 2024 Mar;
143(24):2474-2489.
PMID: 38498036
Patients with T- and natural killer (NK)-cell neoplasms frequently have somatic STAT5B gain-of-function mutations. The most frequent STAT5B mutation is STAT5BN642H, which is known to drive murine T-cell leukemia, although...
5.
Brandstoetter T, Schmoellerl J, Grausenburger R, Kollmann S, Doma E, Huuhtanen J, et al.
Blood
. 2023 Jan;
141(15):1831-1845.
PMID: 36630607
Gain-of-function mutations in the signal transducer and activator of transcription 3 (STAT3) gene are recurrently identified in patients with large granular lymphocytic leukemia (LGLL) and in some cases of natural...
6.
Knab V, Gotthardt D, Klein K, Grausenburger R, Heller G, Menzl I, et al.
Cell Death Dis
. 2021 Oct;
12(11):991.
PMID: 34689158
Triple-negative breast cancer (TNBC) is an aggressive malignant disease that is responsible for approximately 15% of breast cancers. The standard of care relies on surgery and chemotherapy but the prognosis...
7.
Kollmann S, Grausenburger R, Klampfl T, Prchal-Murphy M, Bastl K, Pisa H, et al.
Blood
. 2021 Jul;
138(23):2347-2359.
PMID: 34320169
The transcription factors signal transducer and activator of transcription 5A (STAT5A) and STAT5B are critical in hematopoiesis and leukemia. They are widely believed to have redundant functions, but we describe...
8.
Klein K, Witalisz-Siepracka A, Gotthardt D, Agerer B, Locker F, Grausenburger R, et al.
Front Immunol
. 2021 Jul;
12:650977.
PMID: 34248938
The cyclin-dependent kinase 6 (CDK6) regulates the transition through the G1-phase of the cell cycle, but also acts as a transcriptional regulator. As such CDK6 regulates cell survival or cytokine...
9.
Doma E, Mayer I, Brandstoetter T, Maurer B, Grausenburger R, Menzl I, et al.
Blood Adv
. 2021 Feb;
5(1):39-53.
PMID: 33570624
Studies of molecular mechanisms of hematopoiesis and leukemogenesis are hampered by the unavailability of progenitor cell lines that accurately mimic the situation in vivo. We now report a robust method...
10.
Menzl I, Zhang T, Berger-Becvar A, Grausenburger R, Heller G, Prchal-Murphy M, et al.
Nat Commun
. 2019 Oct;
10(1):4741.
PMID: 31628323
Cyclin-dependent kinases (CDKs) are frequently deregulated in cancer and represent promising drug targets. We provide evidence that CDK8 has a key role in B-ALL. Loss of CDK8 in leukemia mouse...