Regina Vontell
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Explore the profile of Regina Vontell including associated specialties, affiliations and a list of published articles.
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20
Citations
441
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Recent Articles
11.
Albertsson A, Zhang X, Vontell R, Bi D, Bronson R, Supramaniam V, et al.
Am J Pathol
. 2017 Dec;
188(3):757-767.
PMID: 29248460
Brain injury in premature infants, especially periventricular leukomalacia, is an important cause of neurologic disabilities. Inflammation contributes to perinatal brain injury development, but the essential mediators that lead to early-life...
12.
Baburamani A, Sobotka K, Vontell R, Mallard C, Supramaniam V, Thornton C, et al.
Oncotarget
. 2017 Jan;
8(7):12081-12092.
PMID: 28076846
Hypoxia-ischemia (HI) can result in permanent life-long injuries such as motor and cognitive deficits. In response to cellular stressors such as hypoxia, tumor suppressor protein p53 is activated, potently initiating...
13.
Chhor V, Moretti R, Le Charpentier T, Sigaut S, Lebon S, Schwendimann L, et al.
Brain Behav Immun
. 2016 Nov;
63:197-209.
PMID: 27818218
The cognitive and behavioural deficits caused by traumatic brain injury (TBI) to the immature brain are more severe and persistent than TBI in the mature brain. Understanding this developmental sensitivity...
14.
Baburamani A, Miyakuni Y, Vontell R, Supramaniam V, Svedin P, Rutherford M, et al.
Dev Neurosci
. 2015 Apr;
37(4-5):321-37.
PMID: 25823427
Apoptotic mechanisms are centre stage for the development of injury in the immature brain, and caspases have been shown to play a pivotal role during brain development and in response...
15.
Vontell R, Supramaniam V, Wyatt-Ashmead J, Gressens P, Rutherford M, Hagberg H, et al.
J Neuropathol Exp Neurol
. 2015 Feb;
74(3):273-85.
PMID: 25668563
Toll-like receptor-3 (TLR3) has been identified in a variety of intracellular structures (e.g. endosomes and endoplasmic reticulum); it detects viral molecular patterns and damage-associated molecular patterns. We hypothesized that, after...
16.
Segovia K, Vontell R, Lopez-Cruz L, Salamone J, Correa M
Front Behav Neurosci
. 2013 Jun;
7:48.
PMID: 23745109
Considerable evidence indicates that the metabolite of ethanol (EtOH), acetaldehyde, is biologically active. Acetaldehyde can be formed from EtOH peripherally mainly by alcohol dehydrogenase (ADH), and also centrally by catalase....
17.
Supramaniam V, Vontell R, Srinivasan L, Wyatt-Ashmead J, Hagberg H, Rutherford M
Pediatr Res
. 2013 Feb;
73(3):301-9.
PMID: 23364172
Background: The periventricular white matter (PVWM) of the immature preterm brain is selectively vulnerable to a spectrum of injury. Although essential for normal brain development, the presence of resident microglia...
18.
Thornton C, Rousset C, Kichev A, Miyakuni Y, Vontell R, Baburamani A, et al.
Neurol Res Int
. 2012 Feb;
2012:506320.
PMID: 22363841
Fetal/neonatal brain injury is an important cause of neurological disability. Hypoxia-ischemia and excitotoxicity are considered important insults, and, in spite of their acute nature, brain injury develops over a protracted...
19.
Carlsson Y, Schwendimann L, Vontell R, Rousset C, Wang X, Lebon S, et al.
Ann Neurol
. 2011 Jun;
70(5):781-9.
PMID: 21674587
Objective: Perinatal brain injury is a major cause of neurodevelopmental handicaps. Multiple pathways of oxidant stress, inflammation, and excitotoxicity lead to cell damage and death, including caspase-dependent apoptosis. Caspase-2 (Casp2;...
20.
Mingote S, Font L, Farrar A, Vontell R, Worden L, Stopper C, et al.
J Neurosci
. 2008 Sep;
28(36):9037-46.
PMID: 18768698
Goal-directed actions are sensitive to work-related response costs, and dopamine in nucleus accumbens is thought to modulate the exertion of effort in motivated behavior. Dopamine-rich striatal areas such as nucleus...