Molecular Mechanisms of Neonatal Brain Injury

Overview

Journal Neurol Res Int

Publisher Wiley

Specialty Neurology

Date 2012 Feb 25

PMID 22363841

Citations 65

Authors

Claire Thornton

Catherine I Rousset

Anton Kichev

Yasuka Miyakuni

Regina Vontell

Ana A Baburamani

Bobbi Fleiss

Pierre Gressens

Henrik Hagberg

Affiliations

Soon will be listed here.

Abstract

Fetal/neonatal brain injury is an important cause of neurological disability. Hypoxia-ischemia and excitotoxicity are considered important insults, and, in spite of their acute nature, brain injury develops over a protracted time period during the primary, secondary, and tertiary phases. The concept that most of the injury develops with a delay after the insult makes it possible to provide effective neuroprotective treatment after the insult. Indeed, hypothermia applied within 6 hours after birth in neonatal encephalopathy reduces neurological disability in clinical trials. In order to develop the next generation of treatment, we need to know more about the pathophysiological mechanism during the secondary and tertiary phases of injury. We review some of the critical molecular events related to mitochondrial dysfunction and apoptosis during the secondary phase and report some recent evidence that intervention may be feasible also days-weeks after the insult.

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