Reena Halai
Overview
Explore the profile of Reena Halai including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
904
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0
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Recent Articles
1.
Mesch S, Shannon J, Miller D, MacLeod A, Bouche L, Johnston H, et al.
J Med Chem
. 2024 Nov;
67(23):20911-20932.
PMID: 39585325
Aberrant activation of NLRP3 due to persistent tissue damage, misfolded proteins or crystal deposits has been linked to multiple chronic inflammatory disorders such as cryopyrin-associated periodic syndrome (CAPS), neurodegenerative diseases,...
2.
Corcoran S, Halai R, Cooper M
Pharmacol Rev
. 2021 Jun;
73(3):968-1000.
PMID: 34117094
Activation of the Nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome drives release of the proinflammatory cytokines interleukin (IL)-1 and IL-18 and induces pyroptosis (lytic cell death). These events...
3.
Schofield Z, Croker D, Robertson A, Massey N, Donovan C, Tee E, et al.
Sci Rep
. 2018 Dec;
8(1):17819.
PMID: 30546040
Short chain fatty acids (SCFAs) are protective against inflammatory diseases. Free fatty acid receptor 2 (FFA2), is a target of SCFAs however, their selectivity for FFA2 over other FFA receptors...
4.
Kilpinen H, Goncalves A, Leha A, Afzal V, Alasoo K, Ashford S, et al.
Nature
. 2017 Jun;
546(7660):686.
PMID: 28614302
This corrects the article DOI: 10.1038/nature22403.
5.
Kilpinen H, Goncalves A, Leha A, Afzal V, Alasoo K, Ashford S, et al.
Nature
. 2017 May;
546(7658):370-375.
PMID: 28489815
Technology utilizing human induced pluripotent stem cells (iPS cells) has enormous potential to provide improved cellular models of human disease. However, variable genetic and phenotypic characterization of many existing iPS...
6.
Croker D, Monk P, Halai R, Kaeslin G, Schofield Z, Wu M, et al.
Immunol Cell Biol
. 2016 Apr;
94(8):787-95.
PMID: 27108698
The complement cascade is comprised of a highly sophisticated network of innate immune proteins that are activated in response to invading pathogens or tissue injury. The complement activation peptide, C5a,...
7.
Halai R, Croker D, Suen J, Fairlie D, Cooper M
Biosensors (Basel)
. 2015 Jan;
2(3):273-90.
PMID: 25585930
Profiling ligand function on G-protein coupled receptors (GPCRs) typically involves using transfected cells over-expressing a target of interest, a labelled ligand, and intracellular secondary messenger reporters. In contrast, label-free assays...
8.
Halai R, Bellows-Peterson M, Branchett W, Smadbeck J, Kieslich C, Croker D, et al.
Eur J Pharmacol
. 2014 Dec;
745:176-81.
PMID: 25446428
The complement cascade is a highly sophisticated network of proteins that are well regulated and directed in response to invading pathogens or tissue injury. Complement C3a and C5a are key...
9.
Butler M, Hansford K, Blaskovich M, Halai R, Cooper M
J Antibiot (Tokyo)
. 2014 Aug;
67(9):631-44.
PMID: 25118105
Glycopeptide antibiotics have been a key weapon in the fight against bacterial infections for over half a century, with the progenitors, vancomycin (1) and teicoplanin (2), still used extensively. The...
10.
Croker D, Halai R, Kaeslin G, Wende E, Fehlhaber B, Klos A, et al.
Immunol Cell Biol
. 2014 Apr;
92(7):631-9.
PMID: 24777312
The complement system is a major component of our innate immune system, in which the complement proteins C5a and C5a-des Arg bind to two G-protein-coupled receptors: namely, the C5a receptor...