Reem H Elbekai
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Explore the profile of Reem H Elbekai including associated specialties, affiliations and a list of published articles.
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26
Citations
245
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Recent Articles
1.
Paranjpe M, Vidmar T, Denton M, Elbekai R, Mann P, Mckeon M, et al.
Int J Toxicol
. 2021 Mar;
40(4):311-321.
PMID: 33783262
Our experience indicates that extrapolation of doses from the maximum tolerated doses (MTD) derived from 4-week dose range finding (DRF) studies conducted in CByB6F1 may overpredict tolerability and undermine utility...
2.
Paranjpe M, Belich J, Mann P, McKeon M, Elbekai R, Brown C, et al.
Toxicol Pathol
. 2018 Nov;
47(1):18-25.
PMID: 30407148
This article presents the historical control data of spontaneous tumors in Tg.rasH2 published in 2013 (2004-2012) and compares and contrasts it to more recent data collected from 2013 to 2018,...
3.
Paranjpe M, Belich J, Vidmar T, Elbekai R, Mckeon M, Brown C
Int J Toxicol
. 2017 May;
36(4):287-292.
PMID: 28553733
Our recent retrospective analysis of data, collected from 29 Tg.rasH2 mouse carcinogenicity studies, determined how successful the strategy of choosing the high dose for the 26-week studies was based on...
4.
Paranjpe M, Belich J, Richardson D, Vidmar T, Mann P, McKeon M, et al.
Int J Toxicol
. 2016 Jul;
36(1):29-34.
PMID: 27440821
Tg.rasH2 mice are predisposed to hemangiosarcomas. Following the spleen, the uterus is the second most commonly affected organ in the female mice. Female mice are also predisposed to spontaneous vascular...
5.
Paranjpe M, Belich J, McKeon M, Elbekai R, Mann P, Hard G, et al.
Toxicol Pathol
. 2016 Feb;
44(5):633-5.
PMID: 26883151
We report renal tubular adenomas and a carcinoma in 26-week Tg.rasH2 mouse carcinogenicity studies, which have not been reported to date either at our facility or in other published data....
6.
Paranjpe M, Denton M, Vidmar T, Elbekai R
Toxicol Pathol
. 2015 Nov;
44(1):5-8.
PMID: 26578636
We recently conducted a retrospective analysis of data collected from 29 Tg.rasH2 carcinogenicity studies conducted at our facility to determine how successful was the strategy of choosing the high dose...
7.
Thompson C, Wolf J, Elbekai R, Paranjpe M, Seiter J, Chappell M, et al.
Mutat Res Genet Toxicol Environ Mutagen
. 2015 Aug;
789-790:61-6.
PMID: 26232259
Lifetime exposure to high concentrations of hexavalent chromium [Cr(VI)] in drinking water results in intestinal damage and an increase in duodenal tumors in B6C3F1 mice. To assess whether these tumors...
8.
Assessment of the mutagenic potential of Cr(VI) in the oral mucosa of Big Blue® transgenic F344 rats
Thompson C, Young R, Suh M, Dinesdurage H, Elbekai R, Harris M, et al.
Environ Mol Mutagen
. 2015 May;
56(7):621-8.
PMID: 26010270
Exposure to high concentrations of hexavalent chromium [Cr(VI)] in drinking water was associated with an increased incidence of oral tumors in F344 rats in a 2-year cancer bioassay conducted by...
9.
Young R, Thompson C, Dinesdurage H, Elbekai R, Suh M, Rohr A, et al.
Environ Mol Mutagen
. 2015 May;
56(7):629-36.
PMID: 25969955
The Big Blue® (BB) in vivo mutation assay uses transgenic rodents to measure treatment-induced mutations in virtually any tissue. The BB assay can be conducted in rats or mice and...
10.
Paranjpe M, Denton M, Vidmar T, Elbekai R
Toxicol Pathol
. 2014 Nov;
43(5):611-20.
PMID: 25391312
High doses in Tg.rasH2 carcinogenicity studies are usually set at the maximum tolerated dose (MTD), although this dose selection strategy has not been critically evaluated. We analyzed the body weight...