Rebecca L Wallings
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Explore the profile of Rebecca L Wallings including associated specialties, affiliations and a list of published articles.
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16
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579
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Recent Articles
1.
Mark J, Titus A, Staley H, Alvarez S, Mahn S, McFarland N, et al.
bioRxiv
. 2024 Dec;
PMID: 39677794
The motor stage of idiopathic Parkinson's disease (iPD) can be preceded for years by a prodromal stage characterized by non-motor symptoms like REM sleep behavior disorder (RBD). Here, we show...
2.
Wallings R, McFarland K, Staley H, Neighbarger N, Schaake S, Bruggemann N, et al.
Sci Transl Med
. 2024 Nov;
16(772):eadl1535.
PMID: 39504353
Age is the greatest risk factor for many neurodegenerative diseases, yet immune system aging, a contributor to neurodegeneration, is understudied. Genetic variation in the gene affects risk for both familial...
3.
Staley H, Jernigan J, Bolen M, Titus A, Neighbarger N, Cole C, et al.
J Neuroinflammation
. 2024 Nov;
21(1):280.
PMID: 39487477
Genome-wide association studies have identified a protective mutation in the phospholipase C gamma 2 (PLCG2) gene which confers protection against Alzheimer's disease (AD)-associated cognitive decline. Therefore, PLCG2, which is primarily...
4.
Gillett D, Neighbarger N, Cole C, Wallings R, Tansey M
Front Immunol
. 2024 Oct;
15:1417836.
PMID: 39391322
Introduction: Progranulin (PGRN) is a holoprotein that is internalized and taken to the lysosome where it is processed to individual granulins (GRNs). PGRN is critical for successful aging, and insufficient...
5.
Wallings R, Gillett D, Staley H, Mahn S, Mark J, Neighbarger N, et al.
bioRxiv
. 2024 Aug;
PMID: 39211224
Background: Increases in GPNMB are detectable in FTD- cerebrospinal fluid (CSF) and post-mortem brain, and brains of aged -deficient mice. Although no upregulation of GPNMB is observed in the brains...
6.
Gillett D, Neighbarger N, Cole C, Wallings R, Tansey M
bioRxiv
. 2024 Apr;
PMID: 38558966
Progranulin is a holoprotein that is critical for successful aging, and insufficient levels of progranulin are associated with increased risk for developing age-related neurodegenerative diseases like AD, PD, and FTD....
7.
Gillett D, Wallings R, Uriarte Huarte O, Tansey M
J Neuroinflammation
. 2023 Dec;
20(1):286.
PMID: 38037070
Background: Alterations in progranulin (PGRN) expression are associated with multiple neurodegenerative diseases (NDs), including frontotemporal dementia (FTD), Alzheimer's disease (AD), Parkinson's disease (PD), and lysosomal storage disorders (LSDs). Recently, the...
8.
Wallings R, Mark J, Staley H, Gillett D, Neighbarger N, Kordasiewicz H, et al.
Mol Ther Nucleic Acids
. 2023 Nov;
34:102064.
PMID: 38028198
Genetic variation around the gene affects risk for both familial and sporadic Parkinson's disease (PD). LRRK2 levels have become an appealing target for potential PD therapeutics with LRRK2 antisense oligonucleotides...
9.
Wallings R, Mark J, Staley H, Gillett D, Neighbarger N, Kordasiewicz H, et al.
bioRxiv
. 2023 Jul;
PMID: 37503274
Genetic variation around the gene affects risk of both familial and sporadic Parkinson's disease (PD). LRRK2 levels have become an appealing target for potential PD-therapeutics with LRRK2 antisense oligonucleotides (ASOs)...
10.
Houser M, Uriarte Huarte O, Wallings R, Keating C, MacPherson K, Herrick M, et al.
Front Immunol
. 2023 Jan;
13:1056417.
PMID: 36618392
Introduction: Progranulin (PGRN) is a secreted glycoprotein, the expression of which is linked to several neurodegenerative diseases. Although its specific function is still unclear, several studies have linked it with...