Rebecca C Craven
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Explore the profile of Rebecca C Craven including associated specialties, affiliations and a list of published articles.
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18
Citations
584
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Recent Articles
1.
Carmichael J, Yokota H, Craven R, Schmitt A, Wills J
PLoS Pathog
. 2018 May;
14(5):e1007054.
PMID: 29742155
All herpesviruses have mechanisms for passing through cell junctions, which exclude neutralizing antibodies and offer a clear path to neighboring, uninfected cells. In the case of herpes simplex virus type...
2.
Jeon J, Qiao X, Hung I, Mitra A, Desfosses A, Huang D, et al.
J Am Chem Soc
. 2017 Jan;
139(5):2006-2013.
PMID: 28094514
The orthoretroviral capsid protein (CA) assembles into polymorphic capsids, whose architecture, assembly, and stability are still being investigated. The N-terminal and C-terminal domains of CA (NTD and CTD, respectively) engage...
3.
Heyrana K, Goh B, Perilla J, Nguyen T, England M, Bewley M, et al.
J Virol
. 2016 Apr;
90(12):5700-5714.
PMID: 27053549
Unlabelled: Extensive studies of orthoretroviral capsids have shown that many regions of the CA protein play unique roles at different points in the virus life cycle. The N-terminal domain (NTD)...
4.
Goh B, Perilla J, England M, Heyrana K, Craven R, Schulten K
Structure
. 2015 Jun;
23(8):1414-1425.
PMID: 26118533
Defining the molecular interaction between Gag proteins in an assembled hexagonal lattice of immature retrovirus particles is crucial for elucidating the mechanisms of virus assembly and maturation. Recent advances in...
5.
England M, Purdy J, Ropson I, Dalessio P, Craven R
J Virol
. 2014 Apr;
88(13):7170-7.
PMID: 24719425
Unlabelled: During virion maturation, the Rous sarcoma virus (RSV) capsid protein is cleaved from the Gag protein as the proteolytic intermediate CA-SP. Further trimming at two C-terminal sites removes the...
6.
Keller P, Huang R, England M, Waki K, Cheng N, Heymann J, et al.
J Virol
. 2013 Oct;
87(24):13655-64.
PMID: 24109217
Retrovirus maturation involves sequential cleavages of the Gag polyprotein, initially arrayed in a spherical shell, leading to formation of capsids with polyhedral or conical morphology. Evidence suggests that capsids assemble...
7.
Dalessio P, Craven R, Lokhandwala P, Ropson I
Proteins
. 2012 Sep;
81(2):316-25.
PMID: 23011855
An infective retrovirus requires a mature capsid shell around the viral replication complex. This shell is formed by about 1500 capsid protein monomers, organized into hexamer and pentamer rings that...
8.
Butan C, Lokhandwala P, Purdy J, Cardone G, Craven R, Steven A
J Virol
. 2010 Apr;
84(13):6377-86.
PMID: 20427531
Retrovirus assembly is driven by polymerization of the Gag polyprotein as nascent virions bud from host cells. Gag is then processed proteolytically, releasing the capsid protein (CA) to assemble de...
9.
Purdy J, Flanagan J, Ropson I, Craven R
J Mol Biol
. 2009 Apr;
389(2):438-51.
PMID: 19361521
In maturing retroviral virions, CA protein assembles to form a capsid shell that is essential for infectivity. The structure of the two folded domains [N-terminal domain (NTD) and C-terminal domain...
10.
Cardone G, Purdy J, Cheng N, Craven R, Steven A
Nature
. 2009 Feb;
457(7230):694-8.
PMID: 19194444
For a retrovirus such as HIV to be infectious, a properly formed capsid is needed; however, unusually among viruses, retrovirus capsids are highly variable in structure. According to the fullerene...