Rebecca A Lazelle
Overview
Explore the profile of Rebecca A Lazelle including associated specialties, affiliations and a list of published articles.
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Articles
4
Citations
369
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0
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Recent Articles
1.
Gratreak B, Swanson E, Lazelle R, Jelen S, Hoenderop J, Bindels R, et al.
Physiol Rep
. 2020 Jan;
8(1):e14316.
PMID: 31908154
Calcineurin inhibitors (CNIs) are immunosuppressive drugs used to prevent graft rejection after organ transplant. Common side effects include renal magnesium wasting and hypomagnesemia, which may contribute to new-onset diabetes mellitus,...
2.
Terker A, Yarbrough B, Ferdaus M, Lazelle R, Erspamer K, Meermeier N, et al.
J Am Soc Nephrol
. 2015 Dec;
27(8):2436-45.
PMID: 26712527
Excess aldosterone is an important contributor to hypertension and cardiovascular disease. Conversely, low circulating aldosterone causes salt wasting and hypotension. Aldosterone activates mineralocorticoid receptors (MRs) to increase epithelial sodium channel...
3.
Lazelle R, McCully B, Terker A, Himmerkus N, Blankenstein K, Mutig K, et al.
J Am Soc Nephrol
. 2015 Oct;
27(5):1456-64.
PMID: 26432904
Tacrolimus is a widely used immunosuppressive drug that inhibits the phosphatase calcineurin when bound to the 12 kDa FK506-binding protein (FKBP12). When this binding occurs in T cells, it leads...
4.
Terker A, Zhang C, McCormick J, Lazelle R, Zhang C, Meermeier N, et al.
Cell Metab
. 2015 Jan;
21(1):39-50.
PMID: 25565204
Dietary potassium deficiency, common in modern diets, raises blood pressure and enhances salt sensitivity. Potassium homeostasis requires a molecular switch in the distal convoluted tubule (DCT), which fails in familial...