Ray-Yuan Chuang
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Explore the profile of Ray-Yuan Chuang including associated specialties, affiliations and a list of published articles.
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21
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6435
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Recent Articles
1.
Mizutani M, Omori S, Yamane N, Suzuki Y, Glass J, Chuang R, et al.
Front Microbiol
. 2024 Jun;
15:1411609.
PMID: 38881660
Cloning and transfer of long-stranded DNA in the size of a bacterial whole genome has become possible by recent advancements in synthetic biology. For the whole genome cloning and whole...
2.
Pelletier J, Sun L, Wise K, Assad-Garcia N, Karas B, Deerinck T, et al.
Cell
. 2021 Mar;
184(9):2430-2440.e16.
PMID: 33784496
Genomically minimal cells, such as JCVI-syn3.0, offer a platform to clarify genes underlying core physiological processes. Although this minimal cell includes genes essential for population growth, the physiology of its...
3.
Kannan K, Tsvetanova B, Chuang R, Noskov V, Assad-Garcia N, Ma L, et al.
Sci Rep
. 2016 Aug;
6:30714.
PMID: 27489041
Bacteria are indispensable for the study of fundamental molecular biology processes due to their relatively simple gene and genome architecture. The ability to engineer bacterial chromosomes is quintessential for understanding...
4.
Hutchison 3rd C, Chuang R, Noskov V, Assad-Garcia N, Deerinck T, Ellisman M, et al.
Science
. 2016 Mar;
351(6280):aad6253.
PMID: 27013737
We used whole-genome design and complete chemical synthesis to minimize the 1079-kilobase pair synthetic genome of Mycoplasma mycoides JCVI-syn1.0. An initial design, based on collective knowledge of molecular biology combined...
5.
Noskov V, Ma L, Chen S, Chuang R
Biol Proced Online
. 2015 Mar;
17:6.
PMID: 25774095
Background: We have previously established technologies enabling us to engineer the Mycoplasma mycoides genome while cloned in the yeast Saccharomyces cerevisiae, followed by genome transplantation into Mycoplasma capricolum recipient cells...
6.
Suzuki Y, Assad-Garcia N, Kostylev M, Noskov V, Wise K, Karas B, et al.
Genome Res
. 2015 Feb;
25(3):435-44.
PMID: 25654978
The availability of genetically tractable organisms with simple genomes is critical for the rapid, systems-level understanding of basic biological processes. Mycoplasma bacteria, with the smallest known genomes among free-living cellular...
7.
Chandran S, Noskov V, Segall-Shapiro T, Ma L, Whiteis C, Lartigue C, et al.
BMC Genomics
. 2014 Dec;
15:1180.
PMID: 25539750
Background: With the development of several new technologies using synthetic biology, it is possible to engineer genetically intractable organisms including Mycoplasma mycoides subspecies capri (Mmc), by cloning the intact bacterial...
8.
Karas B, Molparia B, Jablanovic J, Hermann W, Lin Y, Dupont C, et al.
J Biol Eng
. 2013 Dec;
7(1):30.
PMID: 24325901
Background: Synthetic genomic approaches offer unique opportunities to use powerful yeast and Escherichia coli genetic systems to assemble and modify chromosome-sized molecules before returning the modified DNA to the target...
9.
Noskov V, Karas B, Young L, Chuang R, Gibson D, Lin Y, et al.
ACS Synth Biol
. 2013 May;
1(7):267-73.
PMID: 23651249
The ability to assemble large pieces of prokaryotic DNA by yeast recombination has great application in synthetic biology, but cloning large pieces of high G+C prokaryotic DNA in yeast can...
10.
Tagwerker C, Dupont C, Karas B, Ma L, Chuang R, Benders G, et al.
Nucleic Acids Res
. 2012 Sep;
40(20):10375-83.
PMID: 22941652
Marine cyanobacteria of the genus Prochlorococcus represent numerically dominant photoautotrophs residing throughout the euphotic zones in the open oceans and are major contributors to the global carbon cycle. Prochlorococcus has...