Ravindra Mylvaganam
Overview
Explore the profile of Ravindra Mylvaganam including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
2837
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Recent Articles
1.
Spitzer A, Gritsch S, Nomura M, Jucht A, Fortin J, Raviram R, et al.
Cancer Cell
. 2024 Apr;
42(5):904-914.e9.
PMID: 38579724
A subset of patients with IDH-mutant glioma respond to inhibitors of mutant IDH (IDHi), yet the molecular underpinnings of such responses are not understood. Here, we profiled by single-cell or...
2.
Jerby-Arnon L, Neftel C, Shore M, Weisman H, Mathewson N, McBride M, et al.
Nat Med
. 2021 Jan;
27(2):289-300.
PMID: 33495604
Synovial sarcoma (SyS) is an aggressive neoplasm driven by the SS18-SSX fusion, and is characterized by low T cell infiltration. Here, we studied the cancer-immune interplay in SyS using an...
3.
Neftel C, Laffy J, Filbin M, Hara T, Shore M, Rahme G, et al.
Cell
. 2019 Jul;
178(4):835-849.e21.
PMID: 31327527
Diverse genetic, epigenetic, and developmental programs drive glioblastoma, an incurable and poorly understood tumor, but their precise characterization remains challenging. Here, we use an integrative approach spanning single-cell RNA-sequencing of...
4.
Karaayvaz M, Cristea S, Gillespie S, Patel A, Mylvaganam R, Luo C, et al.
Nat Commun
. 2018 Sep;
9(1):3588.
PMID: 30181541
Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by extensive intratumoral heterogeneity. To investigate the underlying biology, we conducted single-cell RNA-sequencing (scRNA-seq) of >1500 cells from six primary TNBC....
5.
Filbin M, Tirosh I, Hovestadt V, Shaw M, Escalante L, Mathewson N, et al.
Science
. 2018 Apr;
360(6386):331-335.
PMID: 29674595
Gliomas with histone H3 lysine27-to-methionine mutations (H3K27M-glioma) arise primarily in the midline of the central nervous system of young children, suggesting a cooperation between genetics and cellular context in tumorigenesis....
6.
Venteicher A, Tirosh I, Hebert C, Yizhak K, Neftel C, Filbin M, et al.
Science
. 2017 Apr;
355(6332).
PMID: 28360267
Tumor subclasses differ according to the genotypes and phenotypes of malignant cells as well as the composition of the tumor microenvironment (TME). We dissected these influences in isocitrate dehydrogenase (IDH)-mutant...
7.
Tirosh I, Venteicher A, Hebert C, Escalante L, Patel A, Yizhak K, et al.
Nature
. 2016 Nov;
539(7628):309-313.
PMID: 27806376
Although human tumours are shaped by the genetic evolution of cancer cells, evidence also suggests that they display hierarchies related to developmental pathways and epigenetic programs in which cancer stem...