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Raul Mancilla

Explore the profile of Raul Mancilla including associated specialties, affiliations and a list of published articles. Areas
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Articles 13
Citations 156
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Recent Articles
1.
Espinosa A, Meneses G, Chavarria A, Mancilla R, Pedraza-Chaverri J, Fleury A, et al.
Neurotherapeutics . 2020 Jul; 17(4):1907-1918. PMID: 32632775
Neuroinflammation triggered by the expression of damaged-associated molecular patterns released from dying cells plays a critical role in the pathogenesis of ischemic stroke. However, the benefits from the control of...
2.
Espinosa-Cueto P, Magallanes-Puebla A, Mancilla R
BMC Immunol . 2020 Jun; 21(1):34. PMID: 32517651
Background: Tuberculosis is an important health problem worldwide. The only available vaccine is M. bovis/BCG, an attenuated mycobacterium that activates the innate and the acquired immune system after being phagocytosed...
3.
Magallanes-Puebla A, Espinosa-Cueto P, Lopez-Marin L, Mancilla R
PLoS One . 2018 Dec; 13(12):e0207202. PMID: 30532264
Due to prolonged coevolution with the human being, Mycobacterium tuberculosis has acquired a sophisticated capacity to evade host immunity and persist in a latent state in the infected individual. As...
4.
Espinosa-Cueto P, Magallanes-Puebla A, Castellanos C, Mancilla R
PLoS One . 2017 Aug; 12(8):e0182126. PMID: 28767693
While homeostatic apoptosis is immunologically silent, macrophage apoptosis during Mycobacterium tuberculosis infection can potentially induce an immune response against the mycobacteria. To examine the role of dendritic cells in this...
5.
Garcia-Aguilar T, Espinosa-Cueto P, Magallanes-Puebla A, Mancilla R
J Immunol Res . 2016 Jul; 2016:3845247. PMID: 27413759
Upon Mycobacterium tuberculosis infection, macrophages may undergo apoptosis, which has been considered an innate immune response. The pathways underlying the removal of dead cells in homeostatic apoptosis have been extensively...
6.
Espinosa-Cueto P, Escalera-Zamudio M, Magallanes-Puebla A, Lopez-Marin L, Segura-Salinas E, Mancilla R
BMC Immunol . 2015 Jun; 16:38. PMID: 26100760
Background: Tuberculosis (TB) remains a serious human health problem that affects millions of people in the world. Understanding the biology of Mycobacterium tuberculosis (Mtb) is essential for tackling this devastating...
7.
Polanco C, Castanon-Gonzalez J, Mancilla R, Buhse T, Samaniego J, Gimbel A
Acta Biochim Pol . 2015 May; 62(2):191-6. PMID: 26020061
With almost one third of the world population infected, tuberculosis is one of the most devastating diseases worldwide and it is a major threat to any healthcare system. With the...
8.
Lopez-Rincon G, Mancilla R, Pereira-Suarez A, Martinez-Neri P, Ochoa-Zarzosa A, Munoz-Valle J, et al.
Exp Mol Pathol . 2015 Mar; 98(3):517-26. PMID: 25797370
Increased levels of prolactin (PRL) have recently been associated with carcinogenesis and the exacerbation of autoimmune diseases, and might be involved in the progression of tuberculosis (TB). To investigate the...
9.
Sanchez A, Espinosa P, Garcia T, Mancilla R
Clin Dev Immunol . 2013 Jan; 2012:950503. PMID: 23316255
We describe the association of caspase-dependent and caspase-independent mechanisms in macrophage apoptosis induced by LpqH, a 19 kDa Mycobacterium tuberculosis lipoprotein. LpqH triggered TLR2 activation, with upregulation of death receptors...
10.
Bernal-Fernandez G, Espinosa-Cueto P, Leyva-Meza R, Mancilla N, Mancilla R
Tuberc Res Treat . 2012 May; 2010:517547. PMID: 22567259
Patients with tuberculosis frequently develop anergy, a state of T-cell hyporesponsiveness in which defective T-cell costimulation could be a factor. To know if the expression of T-cell costimulatory molecules was...