Rasmus Linser
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Explore the profile of Rasmus Linser including associated specialties, affiliations and a list of published articles.
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68
Citations
881
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Recent Articles
1.
Aucharova H, Linser R
Biomol NMR Assign
. 2025 Jan;
PMID: 39754705
Cyclic GMP-AMP synthase (cGAS) is a DNA-sensing enzyme that is a member of the nucleotidyltransferase (NTase) family and functions as a DNA sensor. The protein is comprised of a catalytic...
2.
Medina Gomez S, Gonzalez T, Vasa S, Linser R
Angew Chem Int Ed Engl
. 2024 Aug;
63(47):e202411472.
PMID: 39157914
Motional properties of proteins govern recognition, catalysis, and regulation. The dynamics of tightly interacting residues can form intramolecular dynamic networks, dependencies fine-tuned by evolution to optimize a plethora of functional...
3.
Bell D, Lindemann F, Gerland L, Aucharova H, Klein A, Friedrich D, et al.
J Biomol NMR
. 2024 Jun;
78(3):179-192.
PMID: 38904893
Solution NMR is typically applied to biological systems with molecular weights < 40 kDa whereas magic-angle-spinning (MAS) solid-state NMR traditionally targets very large, oligomeric proteins and complexes exceeding 500 kDa...
4.
Medina Gomez S, Visco I, Merino F, Bieling P, Linser R
Angew Chem Int Ed Engl
. 2024 Jun;
63(34):e202403941.
PMID: 38853146
Rho GTPases, master spatial regulators of a wide range of cellular processes, are orchestrated by complex formation with guanine nucleotide dissociation inhibitors (RhoGDIs). These have been thought to possess an...
5.
Xue W, Kolodzeiski P, Aucharova H, Vasa S, Koutsianos A, Pallach R, et al.
Nat Commun
. 2024 May;
15(1):4420.
PMID: 38789474
By combining the porosity of crystalline metal-organic frameworks (MOFs) with the unique processability of the liquid state, melt-quenched MOF glasses offer exciting opportunities for molecular separation. However, progress in this...
6.
Bell D, Lindemann F, Gerland L, Aucharova H, Klein A, Friedrich D, et al.
Res Sq
. 2024 Mar;
PMID: 38464080
Solution NMR is typically applied to biological systems with molecular weights < 40 kDa whereas magic-angle-spinning (MAS) solid-state NMR traditionally targets very large, oligomeric proteins and complexes exceeding 500 kDa...
7.
Aucharova H, Klein A, Medina Gomez S, Soldner B, Vasa S, Linser R
Chem Commun (Camb)
. 2024 Feb;
60(22):3083-3086.
PMID: 38407363
With perdeuteration, solid-state NMR spectroscopy of large proteins suffers from incomplete amide-proton back-exchange. Using a 72 kDa micro-crystalline protein, we show that deuteration exclusively deuterated amino acids, well-established in solution...
8.
Daronkola H, Soldner B, Singh H, Linser R, Vila Verde A
Chembiochem
. 2024 Feb;
25(11):e202400057.
PMID: 38390661
Halophilic organisms have adapted to multi-molar salt concentrations, their cytoplasmic proteins functioning despite stronger attraction between hydrophobic groups. These proteins, of interest in biotechnology because of decreasing fresh-water resources, have...
9.
Kosel B, Bigler K, Buchmuller B, Acharyya S, Linser R, Summerer D
Angew Chem Int Ed Engl
. 2024 Jan;
63(17):e202318837.
PMID: 38284298
Mammalian genomes are regulated by epigenetic cytosine (C) modifications in palindromic CpG dyads. Including canonical cytosine 5-methylation (mC), a total of four different 5-modifications can theoretically co-exist in the two...
10.
Lin T, Engelhard L, Soldner B, Linser R, Summerer D
Adv Sci (Weinh)
. 2024 Jan;
11(11):e2307930.
PMID: 38164822
5-Methylcytosine (5mC) is the central epigenetic mark of mammalian DNA, and plays fundamental roles in chromatin regulation. 5mC is dynamically read and translated into regulatory outputs by methyl-CpG-binding domain (MBD)...