Rashmi G Shah
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Explore the profile of Rashmi G Shah including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
506
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Recent Articles
1.
Dadheech N, Srivastava A, Shah R, Shah G, Gupta S
Sci Rep
. 2022 Dec;
12(1):21496.
PMID: 36513699
Poly(ADP-ribose) polymerase-1 (PARP1), a fundamental DNA repair enzyme, is known to regulate β cell death, replication, and insulin secretion. PARP1 knockout (KO) mice are resistant to diabetes, while PARP1 overactivation...
2.
Blessing C, Apelt K, van den Heuvel D, Gonzalez-Leal C, Rother M, van der Woude M, et al.
Nat Commun
. 2022 Aug;
13(1):4762.
PMID: 35963869
Cells employ global genome nucleotide excision repair (GGR) to eliminate a broad spectrum of DNA lesions, including those induced by UV light. The lesion-recognition factor XPC initiates repair of helix-destabilizing...
3.
Trulsson F, Akimov V, Robu M, van Overbeek N, Berrocal D, Shah R, et al.
Nat Commun
. 2022 May;
13(1):2736.
PMID: 35585066
The ubiquitin-proteasome axis has been extensively explored at a system-wide level, but the impact of deubiquitinating enzymes (DUBs) on the ubiquitinome remains largely unknown. Here, we compare the contributions of...
4.
Shah R, Merlin M, Adant S, Zine-Eddine F, Beauregard J, Shah G
Cancers (Basel)
. 2021 Jan;
13(2).
PMID: 33435224
The peptide receptor radionuclide therapy (PRRT) with Lu-DOTA-octreotate (LuTate) is recommended for different types of neuroendocrine tumors (NETs) which overexpress somatostatin receptors (SSTR). A combination with chemotherapy improves objective response...
5.
Pfeiffer A, Herzog L, Luijsterburg M, Shah R, Rother M, Stoy H, et al.
J Cell Sci
. 2021 Jan;
134(3).
PMID: 33408245
DNA damage-induced SUMOylation serves as a signal for two antagonizing proteins that both stimulate repair of DNA double-strand breaks (DSBs). Here, we demonstrate that the SUMO-dependent recruitment of the deubiquitylating...
6.
Robu M, Shah R, Shah G
Front Cell Dev Biol
. 2020 Dec;
8:590242.
PMID: 33282869
Nucleotide excision repair (NER) is the most versatile DNA repair pathway that removes a wide variety of DNA lesions caused by different types of physical and chemical agents, such as...
7.
Helfricht A, Thijssen P, Rother M, Shah R, Du L, Takada S, et al.
J Exp Med
. 2020 Sep;
217(11).
PMID: 32865561
The autosomal recessive immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome is a genetically heterogeneous disorder. Despite the identification of the underlying gene defects, it is unclear how mutations in...
8.
Purohit N, Shah R, Adant S, Hoepfner M, Shah G, Beauregard J
Oncotarget
. 2018 Jun;
9(37):24693-24706.
PMID: 29872498
For patients with inoperable neuroendocrine tumors (NETs) expressing somatostatin receptors, peptide receptor radionuclide therapy (PRRT) with Lu-[DOTA0-Tyr3]-octreotate (Lu-octreotate) is one of the most promising targeted therapeutic options but it rarely...
9.
Robu M, Shah R, Purohit N, Zhou P, Naegeli H, Shah G
Proc Natl Acad Sci U S A
. 2017 Aug;
114(33):E6847-E6856.
PMID: 28760956
Xeroderma pigmentosum C (XPC) protein initiates the global genomic subpathway of nucleotide excision repair (GG-NER) for removal of UV-induced direct photolesions from genomic DNA. The XPC has an inherent capacity...
10.
Luijsterburg M, de Krijger I, Wiegant W, Shah R, Smeenk G, de Groot A, et al.
Mol Cell
. 2016 Feb;
61(4):547-562.
PMID: 26895424
The response to DNA double-strand breaks (DSBs) requires alterations in chromatin structure to promote the assembly of repair complexes on broken chromosomes. Non-homologous end-joining (NHEJ) is the dominant DSB repair...