Raquel Espin-Palazon
Overview
Explore the profile of Raquel Espin-Palazon including associated specialties, affiliations and a list of published articles.
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13
Citations
469
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Recent Articles
1.
Wellington R, Cheng X, Campbell C, Trapnell C, Espin-Palazon R, Hadland B, et al.
bioRxiv
. 2024 Oct;
PMID: 39386462
Hematopoietic stem cells (HSCs) arise in embryogenesis from a specialized hemogenic endothelium (HE). In this process, HE cells undergo a unique fate change termed endothelial-to-hematopoietic transition, or EHT. While induced...
2.
Campbell C, Calderon R, Pavani G, Cheng X, Barakat R, Snella E, et al.
Nat Commun
. 2024 Sep;
15(1):7787.
PMID: 39242546
Most gene functions have been discovered through phenotypic observations under loss of function experiments that lack temporal control. However, cell signaling relies on limited transcriptional effectors, having to be re-used...
3.
Cheng X, Barakat R, Pavani G, Usha M, Calderon R, Snella E, et al.
Nat Commun
. 2023 Nov;
14(1):7668.
PMID: 37996457
Uncovering the mechanisms regulating hematopoietic specification not only would overcome current limitations related to hematopoietic stem and progenitor cell (HSPC) transplantation, but also advance cellular immunotherapies. However, generating functional human...
4.
Barakat R, Campbell C, Espin-Palazon R
Zebrafish
. 2022 Jun;
19(3):104-108.
PMID: 35704898
Cleavage Under Targets and Release Using Nuclease (CUT&RUN) has emerged as a chromatin profiling strategy that excels traditional methods. Although CUT&RUN has been widely utilized in mammalian cells, its use...
5.
Campbell C, Fursova O, Cheng X, Snella E, McCune A, Li L, et al.
Blood Adv
. 2021 Feb;
5(3):796-811.
PMID: 33560393
Granulin is a pleiotropic protein involved in inflammation, wound healing, neurodegenerative disease, and tumorigenesis. These roles in human health have prompted research efforts to use granulin to treat rheumatoid arthritis...
6.
Espin-Palazon R, Weijts B, Mulero V, Traver D
Trends Cell Biol
. 2017 Sep;
28(1):58-66.
PMID: 28882414
Hematopoietic stem cells (HSCs) have the extraordinary ability to both self-renew and generate all mature blood cell lineages. The ability to produce or expand patient-derived HSCs in vitro would greatly...
7.
Espin-Palazon R, Martinez-Lopez A, Roca F, Lopez-Munoz A, Tyrkalska S, Candel S, et al.
PLoS Pathog
. 2016 Jun;
12(6):e1005699.
PMID: 27351838
TNFα is a pleiotropic pro-inflammatory cytokine with a key role in the activation of the immune system to fight viral infections. Despite its antiviral role, a few viruses might utilize...
8.
Espin-Palazon R, Traver D
Exp Hematol
. 2016 May;
44(7):519-27.
PMID: 27132652
The nuclear factor-κB (NF-κB) family is a crucial transcription factor group known mainly for its role in the regulation of the immune system and its response to infection in vertebrates....
9.
Butko E, Distel M, Pouget C, Weijts B, Kobayashi I, Ng K, et al.
Development
. 2015 Mar;
142(6):1050-61.
PMID: 25758220
The adult blood system is established by hematopoietic stem cells (HSCs), which arise during development from an endothelial-to-hematopoietic transition of cells comprising the floor of the dorsal aorta. Expression of...
10.
Candel S, Sepulcre M, Espin-Palazon R, Tyrkalska S, de Oliveira S, Meseguer J, et al.
Dev Comp Immunol
. 2015 Feb;
50(2):155-65.
PMID: 25681741
TLR4 was the first TLR family member identified in mammals and is responsible for the activation of the immune response by bacterial LPS. Later, MD1 and RP105 were shown to...