Raphael S F Silva
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Explore the profile of Raphael S F Silva including associated specialties, affiliations and a list of published articles.
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12
Citations
88
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Recent Articles
1.
Almeida J, Botelho F, de Souza F, Dos Santos M, da Silva Goncalves A, Rodrigues R, et al.
J Biomol Struct Dyn
. 2021 Jan;
40(11):5229-5242.
PMID: 33416020
The acute respiratory syndrome caused by the SARS-CoV-2, known as COVID-19, has been ruthlessly tormenting the world population for more than six months. However, so far no effective drug or...
2.
Silveira N, Longuinho M, Leitao S, Silva R, Lourenco M, Silva P, et al.
Mater Sci Eng C Mater Biol Appl
. 2015 Oct;
58:458-66.
PMID: 26478333
The aim of this work was to develop and characterize nanoparticles as carriers of lapazine, a phenazine derived from β-lapachone; its antimycobacterial activity is described for the first time as...
3.
Tessarolo N, dos Santos L, Silva R, Azevedo D
J Chromatogr A
. 2013 Jan;
1279:68-75.
PMID: 23357744
The liquid product obtained via the biomass flash pyrolysis is commonly called bio-oil or pyrolysis oil. Bio-oils can be used as sources for chemicals or as fuels, primarily in mixtures...
4.
da Silva E, De Simone C, Goulart M, Andrade C, Silva R, Pinto A
Acta Crystallogr Sect E Struct Rep Online
. 2011 May;
64(Pt 12):o2348.
PMID: 21581322
The title compound, C(20)H(15)Br(2)NO(3), shows the furan ring to adopt a half-chair conformation and the two ring systems to be approximately perpendicular [dihedral angle = 71.0 (2)°]. In the crystal...
5.
Coelho T, Silva R, Pinto A, Pinto M, Scaini C, Moura K, et al.
Tuberculosis (Edinb)
. 2010 Jul;
90(5):293-7.
PMID: 20663716
The increase of incidence of tuberculosis (TB) with resistant strains and HIV co-infection has reinforced the necessity of developing new drugs for its treatment. The reaction of naphthoquinones with aromatic...
6.
Elingold I, Taboas M, Casanova M, Galleano M, Silva R, Menna-Barreto R, et al.
Chem Biol Interact
. 2009 Sep;
182(2-3):213-9.
PMID: 19744469
In order to elucidate the effect on mammal systems of new derivatives from 2-hydroxy-3-allyl-naphthoquinone, alpha-iodinated naphthofuranquinone (NPPN-3223), beta-iodinated naphthofuranquinone (NPPN-3222) and beta-methyl naphthofuranquinone (NPPN-3226) synthesized as possible trypanocidal agents, their...
7.
Menna-Barreto R, Goncalves R, Costa E, Silva R, Pinto A, Oliveira M, et al.
Free Radic Biol Med
. 2009 Jun;
47(5):644-53.
PMID: 19501647
Despite ongoing efforts, the current treatment for Chagas disease is still unsatisfactory, mainly because of the severe side effects and variable efficacy of the available nitroheterocycles. Our group has been...
8.
Silva R, Pinto M, Goulart M, de Souza Filho J, Neves Jr I, Lourenco M, et al.
Eur J Med Chem
. 2008 Jul;
44(5):2334-7.
PMID: 18662840
We report here an alternative to the MCPBA or ozonolysis-based oxidation methods of quinoxaline-featuring compounds prepared from beta-lapachones. The use of peracetic acid allowed a simple preparation of the corresponding...
9.
da Silva Jr E, Menna-Barreto R, Pinto M, Silva R, Teixeira D, de Souza M, et al.
Eur J Med Chem
. 2007 Nov;
43(8):1774-80.
PMID: 18045742
[1,2,3]-Triazole derivatives of nor-beta-lapachone were synthesized and assayed against the infective bloodstream trypomastigote form of Trypanosoma cruzi, the etiological agent of Chagas disease. All the derivatives were more active than...
10.
Silva R, Leitao G, Brum T, Lobato A, Pinto M, Pinto A
J Chromatogr A
. 2007 Apr;
1151(1-2):197-202.
PMID: 17408681
This work describes the application of counter-current chromatography (CCC) as a useful, fast and economic alternative for the isolation and purification of heterocyclic derivatives from lapachol and beta-lapachone, two naturally...