Raphael Chevre
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Explore the profile of Raphael Chevre including associated specialties, affiliations and a list of published articles.
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Articles
28
Citations
928
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Recent Articles
21.
Pello O, Chevre R, Laoui D, de Juan A, Lolo F, Andres-Manzano M, et al.
PLoS One
. 2012 Oct;
7(9):e45399.
PMID: 23028984
Although tumor-associated macrophages (TAMs) are involved in tumor growth and metastasis, the mechanisms controlling their pro-tumoral activities remain largely unknown. The transcription factor c-MYC has been recently shown to regulate...
22.
Garcia-Bernal D, Redondo-Munoz J, Dios-Esponera A, Chevre R, Bailon E, Garayoa M, et al.
J Pathol
. 2012 Jun;
229(1):36-48.
PMID: 22711564
Myeloma cell adhesion dependent on α4β1 integrin is crucial for the progression of multiple myeloma (MM). The α4β1-dependent myeloma cell adhesion is up-regulated by the chemokine CXCL12, and pharmacological blockade...
23.
Le Bihan O, Chevre R, Mornet S, Garnier B, Pitard B, Lambert O
Nucleic Acids Res
. 2010 Nov;
39(4):1595-609.
PMID: 21078679
Cationic lipids are used for delivering nucleic acids (lipoplexes) into cells for both therapeutic and biological applications. A better understanding of the identified key-steps, including endocytosis, endosomal escape and nuclear...
24.
Chevre R, Le Bihan O, Beilvert F, Chatin B, Barteau B, Mevel M, et al.
Nucleic Acids Res
. 2010 Oct;
39(4):1610-22.
PMID: 20952409
Amphiphilic block copolymers have been developed recently for their efficient, in vivo transfection activities in various tissues. Surprisingly, we observed that amphiphilic block copolymers such as Lutrol® do not allow...
25.
Labas R, Beilvert F, Barteau B, David S, Chevre R, Pitard B
Genetica
. 2009 Sep;
138(2):153-68.
PMID: 19763845
Synthetic gene delivery systems represent an attractive alternative to viral vectors for DNA transfection. Cationic lipids are one of the most widely used non-viral vectors for the delivery of DNA...
26.
Chisholm E, Vassaux G, Martin-Duque P, Chevre R, Lambert O, Pitard B, et al.
Cancer Res
. 2009 Mar;
69(6):2655-62.
PMID: 19258509
The lack of safe and efficient systemic gene delivery vectors has largely reduced the potential of gene therapy in the clinic. Previously, we have reported that polypropylenimine dendrimer PPIG3/DNA nanoparticles...
27.
Barteau B, Chevre R, Letrou-Bonneval E, Labas R, Lambert O, Pitard B
Curr Gene Ther
. 2008 Oct;
8(5):313-23.
PMID: 18855629
Gene therapy is based on the vectorization of nucleic acids to target cells and their subsequent expression. Cationic lipids and polymers are the most widely used vectors for the delivery...
28.
Letrou-Bonneval E, Chevre R, Lambert O, Costet P, Andre C, Tellier C, et al.
J Gene Med
. 2008 Sep;
10(11):1198-209.
PMID: 18816485
Background: Numerous synthetic cationic vectors have been synthesized and are successfully used for in vitro gene transfer but an excess of positive charges can lead to cytotoxicity and does not...
29.
Richard-Fiardo P, Payen E, Chevre R, Zuber J, Letrou-Bonneval E, Beuzard Y, et al.
Hum Gene Ther
. 2008 Mar;
19(4):331-42.
PMID: 18341422
Numerous studies using erythropoietin (EPO) gene delivery vectors, either viral or nonviral, have shown uncontrolled EPO expression leading to transient or sustained erythrocytosis and, more recently, severe autoimmune anemia. Therefore,...
30.
Desigaux L, Sainlos M, Lambert O, Chevre R, Letrou-Bonneval E, Vigneron J, et al.
Proc Natl Acad Sci U S A
. 2007 Oct;
104(42):16534-9.
PMID: 17923669
RNA interference requires efficient delivery of small double-stranded RNA molecules into the target cells and their subsequent incorporation into RNA-induced silencing complexes. Although current cationic lipids commonly used for DNA...