Raoul J de Groot
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Explore the profile of Raoul J de Groot including associated specialties, affiliations and a list of published articles.
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53
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3572
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Recent Articles
11.
Rabouw H, Visser L, Passchier T, Langereis M, Liu F, Giansanti P, et al.
Nat Microbiol
. 2020 Jul;
5(11):1361-1373.
PMID: 32690955
Eukaryotic cells, when exposed to environmental or internal stress, activate the integrated stress response (ISR) to restore homeostasis and promote cell survival. Specific stress stimuli prompt dedicated stress kinases to...
12.
Visser L, Aloise C, Swatek K, Medina G, Olek K, Rabouw H, et al.
PLoS Pathog
. 2020 Jul;
16(7):e1008702.
PMID: 32667958
The type I interferon response is an important innate antiviral pathway. Recognition of viral RNA by RIG-I-like receptors (RLRs) activates a signaling cascade that leads to type I interferon (IFN-α/β)...
13.
de Vries A, Horzinek M, Rottier P, de Groot R
Semin Virol
. 2020 Apr;
8(1):33-47.
PMID: 32288441
Viruses in the families Arteriviridae and Coronaviridae have enveloped virions which contain nonsegmented, positive-stranded RNA, but the constituent genera differ markedly in genetic complexity and virion structure. Nevertheless, there are...
14.
Tortorici M, Walls A, Lang Y, Wang C, Li Z, Koerhuis D, et al.
Nat Struct Mol Biol
. 2019 Jun;
26(6):481-489.
PMID: 31160783
Coronaviruses cause respiratory tract infections in humans and outbreaks of deadly pneumonia worldwide. Infections are initiated by the transmembrane spike (S) glycoprotein, which binds to host receptors and fuses the...
15.
Visser L, Langereis M, Rabouw H, Wahedi M, Muntjewerff E, de Groot R, et al.
J Virol
. 2019 Mar;
93(10).
PMID: 30867299
Most viruses have acquired mechanisms to suppress antiviral alpha/beta interferon (IFN-α/β) and stress responses. Enteroviruses (EVs) actively counteract the induction of IFN-α/β gene transcription and stress granule (SG) formation, which...
16.
Hulswit R, Lang Y, Bakkers M, Li W, Li Z, Schouten A, et al.
Proc Natl Acad Sci U S A
. 2019 Jan;
116(7):2681-2690.
PMID: 30679277
Human betacoronaviruses OC43 and HKU1 are endemic respiratory pathogens and, while related, originated from independent zoonotic introductions. OC43 is in fact a host-range variant of the species , and more...
17.
Small molecule ISRIB suppresses the integrated stress response within a defined window of activation
Rabouw H, Langereis M, Anand A, Visser L, de Groot R, Walter P, et al.
Proc Natl Acad Sci U S A
. 2019 Jan;
116(6):2097-2102.
PMID: 30674674
Activation of the integrated stress response (ISR) by a variety of stresses triggers phosphorylation of the α-subunit of translation initiation factor eIF2. P-eIF2α inhibits eIF2B, the guanine nucleotide exchange factor...
18.
Visser L, Medina G, Rabouw H, de Groot R, Langereis M, De Los Santos T, et al.
J Virol
. 2018 Nov;
93(2).
PMID: 30404792
Like other viruses, the picornavirus foot-and-mouth disease virus (FMDV; genus ), one of the most notorious pathogens in the global livestock industry, needs to navigate antiviral host responses to establish...
19.
Guo H, Rabouw H, Slomp A, Dai M, van der Vegt F, van Lent J, et al.
PLoS Pathog
. 2018 Aug;
14(8):e1007233.
PMID: 30102740
Interactions of influenza A virus (IAV) with sialic acid (SIA) receptors determine viral fitness and host tropism. Binding to mucus decoy receptors and receptors on epithelial host cells is determined...
20.
Baggen J, Hurdiss D, Zocher G, Mistry N, Roberts R, Slager J, et al.
Proc Natl Acad Sci U S A
. 2017 Dec;
115(2):397-402.
PMID: 29284752
Acute hemorrhagic conjunctivitis (AHC) is a painful, contagious eye disease, with millions of cases in the last decades. Coxsackievirus A24 (CV-A24) was not originally associated with human disease, but in...