Randy L Johnson
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Explore the profile of Randy L Johnson including associated specialties, affiliations and a list of published articles.
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112
Citations
7841
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Recent Articles
11.
Song S, Chen Q, Li Y, Lei G, Scott A, Huo L, et al.
Gut
. 2021 Jan;
70(12):2238-2248.
PMID: 33487592
Objective: Gastro-oesophageal cancers (GEC) are resistant to therapy and lead to poor prognosis. The cancer stem cells (CSCs) and antiapoptotic pathways often confer therapy resistance. We sought to elucidate the...
12.
Ajani J, Xu Y, Huo L, Wang R, Li Y, Wang Y, et al.
Gut
. 2020 Apr;
70(1):55-66.
PMID: 32345613
Objective: Peritoneal carcinomatosis (PC; malignant ascites or implants) occurs in approximately 45% of advanced gastric adenocarcinoma (GAC) patients and associated with a poor survival. The molecular events leading to PC...
13.
Li Q, Sun Y, Jarugumilli G, Liu S, Dang K, Cotton J, et al.
Cell Stem Cell
. 2020 Apr;
26(5):675-692.e8.
PMID: 32259481
Intestinal homeostasis is tightly regulated by complex yet poorly understood signaling networks. Here, we demonstrate that Lats1/2, the core Hippo kinases, are essential to maintain Wnt pathway activity and intestinal...
14.
Song S, Li Y, Xu Y, Ma L, Pizzi M, Jin J, et al.
Mol Oncol
. 2020 Mar;
14(6):1410-1426.
PMID: 32175692
Hippo/YAP1 signaling is a major regulator of organ size, cancer stemness, and aggressive phenotype. Thus, targeting YAP1 may provide a novel therapeutic strategy for tumors with high YAP1 expression in...
15.
Li H, Li Q, Dang K, Ma S, Cotton J, Yang S, et al.
Cell Rep
. 2019 Dec;
29(10):3200-3211.e4.
PMID: 31801083
Uveal melanoma (UM), the most common ocular malignancy, is characterized by GNAQ/11 mutations. Hippo/YAP and Ras/mitogen-activated protein kinase (MAPK) emerge as two important signaling pathways downstream of G protein alpha...
16.
Song S, Wang Z, Li Y, Ma L, Jin J, Scott A, et al.
Mol Cancer Res
. 2019 Dec;
18(3):390-402.
PMID: 31796534
Despite established functions of PPARδ in lipid metabolism and tumorigenesis, the mechanisms underlying its role in gastric cancer are undefined. Here, we demonstrate that SOX9 was dramatically induced by stably...
17.
Kapoor A, Yao W, Ying H, Hua S, Liewen A, Wang Q, et al.
Cell
. 2019 Nov;
179(5):1239.
PMID: 31730860
No abstract available.
18.
Liu J, Gao M, Nipper M, Deng J, Sharkey F, Johnson R, et al.
PLoS Biol
. 2019 Sep;
17(9):e3000418.
PMID: 31513574
Damaged acinar cells play a passive role in activating pancreatic stellate cells (PSCs) via recruitment of immune cells that subsequently activate PSCs. However, whether acinar cells directly contribute to PSC...
19.
Johnson R
Sci China Life Sci
. 2019 Aug;
62(12):1609-1616.
PMID: 31463737
A traditional view of cellular differentiation is unidirectional: progenitor cells adopt specific fates in response to environmental cues resulting in deployment of cell-specific gene expression programs and acquisition of unique...
20.
Tsoi M, Morin M, Rico C, Johnson R, Paquet M, Gevry N, et al.
FASEB J
. 2019 Jul;
33(10):10819-10832.
PMID: 31268774
Recent reports suggest that the Hippo signaling pathway influences ovarian follicle development; however, its exact roles remain unknown. Here, we examined the ovarian functions of the Hippo kinases large tumor...