Randall N Pittman
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Explore the profile of Randall N Pittman including associated specialties, affiliations and a list of published articles.
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10
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Recent Articles
1.
Reina C, Nabet B, Young P, Pittman R
Cell Stress Chaperones
. 2012 Jul;
17(6):729-42.
PMID: 22777893
Regulation of basal and induced levels of hsp70 is critical for cellular homeostasis. Ataxin-3 is a deubiquitinase with several cellular functions including transcriptional regulation and maintenance of protein homeostasis. While...
2.
Reina C, Zhong X, Pittman R
Hum Mol Genet
. 2009 Oct;
19(2):235-49.
PMID: 19843543
Spinocerebellar ataxia type 3 (SCA3)/Machado Joseph disease results from expansion of the polyglutamine domain in ataxin-3 (Atx3). Atx3 is a transcriptional co-repressor, as well as a deubiquitinating enzyme that appears...
3.
Bilen J, Liu N, Burnett B, Pittman R, Bonini N
Mol Cell
. 2006 Oct;
24(1):157-63.
PMID: 17018300
Nine human neurodegenerative diseases are due to expansion of a CAG repeat- encoding glutamine within the open reading frame of the respective genes. Polyglutamine (polyQ) expansion confers dominant toxicity, resulting...
4.
Orlando K, Pittman R
Exp Cell Res
. 2006 Aug;
312(17):3298-311.
PMID: 16904666
Apoptotic cells undergo a number of changes to prepare for phagocytosis; most occur during the execution phase of apoptosis, when dying cells undergo shrinkage and/or fragmentation into apoptotic bodies and...
5.
Zhong X, Pittman R
Hum Mol Genet
. 2006 Jul;
15(16):2409-20.
PMID: 16822850
Expansion of a polyglutamine tract in ataxin-3 (AT3) results in spinocerebellar ataxia type 3/Machado-Joseph disease, one of the nine polyglutamine neurodegenerative diseases. Understanding the normal functions of AT3 as well...
6.
Orlando K, Stone N, Pittman R
Exp Cell Res
. 2005 Nov;
312(1):5-15.
PMID: 16259978
During the execution phase of apoptosis, a cell undergoes cytoplasmic and nuclear changes that prepare it for death and phagocytosis. The end-point of the execution phase is condensation into a...
7.
Burnett B, Pittman R
Proc Natl Acad Sci U S A
. 2005 Mar;
102(12):4330-5.
PMID: 15767577
The polyglutamine-containing neurodegenerative protein ataxin 3 (AT3) has deubiquitylating activity and binds ubiquitin chains with a preference for chains of four or more ubiquitins. Here we characterize the deubiquitylating activity...
8.
Burnett B, Li F, Pittman R
Hum Mol Genet
. 2003 Oct;
12(23):3195-205.
PMID: 14559776
The ubiquitin-proteasome pathway is critically involved in the pathology of neurodegenerative diseases characterized by protein misfolding and aggregation. Data in the present study suggest that the polyglutamine neurodegenerative disease protein,...
9.
Raghupathi R, Muir J, Fulp C, Pittman R, McIntosh T
Exp Neurol
. 2003 Oct;
183(2):438-48.
PMID: 14552884
The regional activation (via phosphorylation) of c-Jun N-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) signaling pathways was examined using immunoblotting and immunohistochemistry following experimental brain injury. Anesthetized rats were...
10.
Li F, Macfarlan T, Pittman R, Chakravarti D
J Biol Chem
. 2002 Sep;
277(47):45004-12.
PMID: 12297501
The mechanisms of pathology for the family of polyglutamine disease proteins are unknown; however, recently it was shown that several of these proteins inhibit transcription suggesting that transcriptional repression may...