Ramon C Sun
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Explore the profile of Ramon C Sun including associated specialties, affiliations and a list of published articles.
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62
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1138
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Recent Articles
1.
Clarke H, Hawkinson T, Shedlock C, Medina T, Ribas R, Wu L, et al.
Nat Metab
. 2025 Mar;
PMID: 40069440
Lung adenocarcinoma (LUAD) is an aggressive cancer defined by oncogenic drivers and metabolic reprogramming. Here we leverage next-generation spatial screens to identify glycogen as a critical and previously underexplored oncogenic...
2.
Zhu B, Pitts M, Buoncristiani M, Bryant L, Lopez-Nunez O, Gurria J, et al.
Oncogene
. 2025 Feb;
PMID: 39956863
MYCN-amplification is a genetic hallmark of ~40% of high-risk neuroblastomas (NBs). Altered glycosylation is a common feature of adult cancer progression, but little is known about how genetic signatures such...
3.
Fuller D, Rana S, Thakre P, Benevides E, Pope M, Todd A, et al.
bioRxiv
. 2025 Jan;
PMID: 39763722
Absence of functional acid-α-glucosidase (GAA) leads to early-onset Pompe disease with cardiorespiratory and neuromuscular failure. A novel Pompe rat model ( ) was used to test the hypothesis that neonatal...
4.
Park S, Fadhul T, Conroy L, Clarke H, Sun R, Wallenius K, et al.
JCI Insight
. 2024 Oct;
9(23).
PMID: 39418102
Excessive fructose intake is a risk factor for the development of obesity and its complications. Targeting ketohexokinase (KHK), the first enzyme of fructose metabolism, has been investigated for the management...
5.
Colpaert M, Singh P, Donohue K, Pires N, Fuller D, Corti M, et al.
Neurotherapeutics
. 2024 Sep;
21(5):e00446.
PMID: 39277505
Glycogen storage diseases (GSDs) comprise a group of inherited metabolic disorders characterized by defects in glycogen metabolism, leading to abnormal glycogen accumulation in multiple tissues, most notably affecting the liver,...
6.
Taylor C, Mendenhall L, Sunshine M, Wilson J, Calulot C, Sun R, et al.
J Neurophysiol
. 2024 May;
132(1):23-33.
PMID: 38748407
The apolipoprotein E () gene has been studied due to its influence on Alzheimer's disease (AD) development and work in an mouse model recently demonstrated impaired respiratory motor plasticity following...
7.
Liu Y, Kwok W, Yoon H, Ryu J, Stevens P, Hawkinson T, et al.
J Neurosci
. 2024 Apr;
44(20).
PMID: 38565291
Microglia undergo two-stage activation in neurodegenerative diseases, known as disease-associated microglia (DAM). TREM2 mediates the DAM2 stage transition, but what regulates the first DAM1 stage transition is unknown. We report...
8.
Ullman J, Mellem K, Xi Y, Ramanan V, Merritt H, Choy R, et al.
Sci Transl Med
. 2024 Jan;
16(730):eadf1691.
PMID: 38232139
Glycogen synthase 1 (GYS1), the rate-limiting enzyme in muscle glycogen synthesis, plays a central role in energy homeostasis and has been proposed as a therapeutic target in multiple glycogen storage...
9.
Wilson J, Kigerl K, Sunshine M, Taylor C, Speed S, Rose B, et al.
bioRxiv
. 2024 Jan;
PMID: 38187534
Research Highlights: Cervical spinal cord injury (SCI) causes transient gut dysbiosis and persistent gastrointestinal (GI) pathology.Treatment with probiotics after SCI leads to a healthier GI tract and improved respiratory motor...
10.
Ma X, Shedlock C, Medina T, Ribas R, Clarke H, Hawkinson T, et al.
bioRxiv
. 2023 Dec;
PMID: 38077043
High-resolution spatial imaging is transforming our understanding of foundational biology. Spatial metabolomics is an emerging field that enables the dissection of the complex metabolic landscape and heterogeneity from a thin...