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Ramanujam Srinivasan

Explore the profile of Ramanujam Srinivasan including associated specialties, affiliations and a list of published articles. Areas
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Articles 36
Citations 283
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Recent Articles
1.
Poddar S, Chakraborty J, Gayathri P, Srinivasan R
Cytoskeleton (Hoboken) . 2024 Sep; PMID: 39230425
FtsZ forms a ring-like assembly at the site of division in bacteria. It is the first protein involved in the formation of the divisome complex to split the cell into...
2.
Poddar S, Roy S, Sharma A, Srinivasan R
J Vis Exp . 2024 May; (206). PMID: 38738900
Bacterial cytoskeletal proteins such as FtsZ and MreB perform essential functions such as cell division and cell shape maintenance. Further, FtsZ and MreB have emerged as important targets for novel...
3.
Chakraborty J, Poddar S, Dutta S, Bahulekar V, Harne S, Srinivasan R, et al.
J Biol Chem . 2024 May; 300(6):107336. PMID: 38718863
FtsZ, the tubulin homolog essential for bacterial cell division, assembles as the Z-ring at the division site, and directs peptidoglycan synthesis by treadmilling. It is unclear how FtsZ achieves kinetic...
4.
Mallik S, Dodia H, Ghosh A, Srinivasan R, Good L, Raghav S, et al.
Microbiol Spectr . 2023 Apr; 11(3):e0286322. PMID: 37014250
The peptidoglycan (PG) layer, a crucial component of the tripartite envelope, is required to maintain cellular integrity, protecting the cells from mechanical stress resulting from intracellular turgor pressure. Thus, coordinating...
5.
Sharma A, Poddar S, Chakraborty J, Nayak B, Kalathil S, Mitra N, et al.
Mol Biol Cell . 2023 Jan; 34(3):ar16. PMID: 36652338
Bacterial cell division proteins, especially the tubulin homologue FtsZ, have emerged as strong targets for developing new antibiotics. Here, we have utilized the fission yeast heterologous expression system to develop...
6.
Mishra D, Srinivasan R
Front Microbiol . 2022 Jun; 13:856547. PMID: 35694299
Partitioning the replicated genetic material is a crucial process in the cell cycle program of any life form. In bacteria, many plasmids utilize cytoskeletal proteins that include ParM and TubZ,...
7.
Pande V, Mitra N, Bagde S, Srinivasan R, Gayathri P
J Cell Biol . 2022 Apr; 221(5). PMID: 35377392
MreB, the bacterial ancestor of eukaryotic actin, is responsible for shape in most rod-shaped bacteria. Despite belonging to the actin family, the relevance of nucleotide-driven polymerization dynamics for MreB function...
8.
Mishra D, Jakhmola A, Srinivasan R
Plasmid . 2022 Jan; 119-120:102617. PMID: 35041919
The rapid emergence and spread of antibiotic resistance is a growing global burden. Antibiotic resistance is often associated with large single or low copy number plasmids, which rely upon cytoskeletal...
9.
Mishra D, Pahujani S, Mitra N, Srivastava A, Srinivasan R
J Membr Biol . 2021 Jan; 254(3):243-257. PMID: 33427942
Stable maintenance and partitioning of the 'Fertility' plasmid or the F plasmid in its host Escherichia coli require the function of a ParA superfamily of proteins known as SopA. The...
10.
Jena P, Bhattacharya M, Bhattacharjee G, Satpati B, Mukherjee P, Senapati D, et al.
Nanoscale . 2020 Jan; 12(6):3731-3749. PMID: 31993609
The actin cytoskeleton is required for the maintenance of the cell shape and viability of bacteria. It remains unknown to which extent nanoparticles (NPs) can orchestrate the mechanical instability by...