Ralph Plehm
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Explore the profile of Ralph Plehm including associated specialties, affiliations and a list of published articles.
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35
Citations
1280
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Recent Articles
1.
Grabowski K, Herlan L, Witten A, Qadri F, Eisenreich A, Lindner D, et al.
Hypertens Res
. 2021 Dec;
45(2):292-307.
PMID: 34916661
Treatment of hypertension-mediated cardiac damage with left ventricular (LV) hypertrophy (LVH) and heart failure remains challenging. To identify novel targets, we performed comparative transcriptome analysis between genetic models derived from...
2.
Ercu M, Marko L, Schachterle C, Tsvetkov D, Cui Y, Maghsodi S, et al.
Circulation
. 2020 Jun;
142(2):133-149.
PMID: 32524868
Background: High blood pressure is the primary risk factor for cardiovascular death worldwide. Autosomal dominant hypertension with brachydactyly clinically resembles salt-resistant essential hypertension and causes death by stroke before 50...
3.
Jarve A, Todiras M, Kny M, Fischer F, Kraemer J, Wessel N, et al.
Front Physiol
. 2019 Jan;
9:1930.
PMID: 30687131
Spinal cord injury (SCI) above mid-thoracic levels leads to autonomic dysfunction affecting both the cardiovascular system and thermoregulation. The renin-angiotensin system (RAS) which is a potent regulator of blood pressure,...
4.
Barros C, Schadock I, Sihn G, Rother F, Xu P, Popova E, et al.
Front Med (Lausanne)
. 2018 Dec;
5:338.
PMID: 30560131
Acute intra-renal infusion of bradykinin increases diuresis and natriuresis via inhibition of vasopressin activity. However, the consequences of chronically increased bradykinin in the kidneys have not yet been studied. A...
5.
Buttgereit J, Shanks J, Li D, Hao G, Athwal A, Langenickel T, et al.
Cardiovasc Res
. 2016 Aug;
112(3):637-644.
PMID: 27496871
Aims: B-type natriuretic peptide (BNP)-natriuretic peptide receptor A (NPR-A) receptor signalling inhibits cardiac sympathetic neurotransmission, although C-type natriuretic peptide (CNP) is the predominant neuropeptide of the nervous system with expression...
6.
Balkaya M, Prinz V, Custodis F, Gertz K, Kronenberg G, Kroeber J, et al.
Stroke
. 2011 Sep;
42(11):3258-64.
PMID: 21921276
Background And Purpose: Chronic stress is associated with increased stroke risk. However, the underlying pathophysiological mechanisms are poorly understood. We examined the effects of chronic stress on endothelial function and...
7.
Hilzendeger A, Morais R, Todiras M, Plehm R, da Costa Goncalves A, Qadri F, et al.
J Mol Med (Berl)
. 2010 Jul;
88(9):899-907.
PMID: 20614101
Leptin is a hormone related to metabolism. It also influences blood pressure, but the mechanisms triggered in this process are not yet elucidated. Angiotensin-I converting enzyme (ACE) regulates cardiovascular functions...
8.
Hilzendeger A, Da Costa Goncalves A, Plehm R, Diedrich A, Gross V, Pesquero J, et al.
J Mol Med (Berl)
. 2009 Dec;
88(4):383-90.
PMID: 20012594
The leptin-deficient ob/ob mice are insulin resistant and obese. However, the control of blood pressure in this model is not well defined. The goal of this study was to evaluate...
9.
Hanada R, Leibbrandt A, Hanada T, Kitaoka S, Furuyashiki T, Fujihara H, et al.
Nature
. 2009 Nov;
462(7272):505-9.
PMID: 19940926
Receptor-activator of NF-kappaB ligand (TNFSF11, also known as RANKL, OPGL, TRANCE and ODF) and its tumour necrosis factor (TNF)-family receptor RANK are essential regulators of bone remodelling, lymph node organogenesis...
10.
Park J, Theuer S, Kirsch T, Lindschau C, Klinge U, Heuser A, et al.
Hypertension
. 2009 Jul;
54(2):359-64.
PMID: 19564549
Growth arrest-specific protein 6 (Gas 6) is involved in inflammatory kidney diseases, vascular remodeling, cell adhesion, and thrombus formation. We explored a role for Gas 6 in aldosterone-induced target organ...