Ralph J DiLeone
Overview
Explore the profile of Ralph J DiLeone including associated specialties, affiliations and a list of published articles.
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91
Citations
7435
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Recent Articles
1.
LaRocco K, Villiamma P, Hill J, Russell M, DiLeone R, Groman S
Biol Psychiatry Glob Open Sci
. 2025 Mar;
5(3):100450.
PMID: 40083740
Background: Problematic opioid use that emerges in a subset of individuals may be due to preexisting disruptions in the biobehavioral mechanisms that regulate drug use. The identity of these mechanisms...
2.
Trinko J, Foscue E, Kong E, Basu A, Corstens A, Thompson S, et al.
J Clin Invest
. 2024 Nov;
134(22).
PMID: 39545408
No abstract available.
3.
Worhunsky P, Mignosa M, Gallezot J, Pittman B, Nabulsi N, Stryjewski A, et al.
Biol Psychiatry
. 2024 Oct;
97(6):651-658.
PMID: 39395473
Background: Dopaminergic tone and phasic release have transdiagnostic relevance. Preclinical research suggests that the active form of vitamin D, calcitriol, increases subcortical tyrosine hydroxylase, D/D receptors, and amphetamine-stimulated dopamine release...
4.
LaRocco K, Villiamma P, Hill J, Russell M, DiLeone R, Groman S
bioRxiv
. 2024 Apr;
PMID: 38645212
Problematic opioid use that emerges in a subset of individuals may be due to pre-existing disruptions in the biobehavioral mechanisms that regulate drug use. The identity of these mechanisms is...
5.
Jiang C, DiLeone R, Pittenger C, Duman R
Transl Psychiatry
. 2024 Feb;
14(1):90.
PMID: 38346984
Recent studies have implicated the endogenous opioid system in the antidepressant actions of ketamine, but the underlying mechanisms remain unclear. We used a combination of pharmacological, behavioral, and molecular approaches...
6.
van Galen K, Schrantee A, Ter Horst K, la Fleur S, Booij J, Constable R, et al.
Nat Metab
. 2023 Jun;
5(6):1059-1072.
PMID: 37308722
Post-ingestive nutrient signals to the brain regulate eating behaviour in rodents, and impaired responses to these signals have been associated with pathological feeding behaviour and obesity. To study this in...
7.
Asch R, Pothula S, Toyonaga T, Fowles K, Groman S, Garcia-Milian R, et al.
Neuropsychopharmacology
. 2022 Sep;
48(3):489-497.
PMID: 36100654
Clinical investigations suggest involvement of the metabotropic glutamate receptor 5 (mGluR5) in the pathophysiology of fear learning that underlies trauma-related disorders. Here, we utilized a 4-day fear learning paradigm combined...
8.
Lee B, Pothula S, Wu M, Kang H, Girgenti M, Picciotto M, et al.
Mol Psychiatry
. 2022 Apr;
27(5):2580-2589.
PMID: 35418600
N-methyl-D-aspartate receptor (NMDAR) modulators have recently received increased attention as potential therapeutics for posttraumatic stress disorder (PTSD). Here, we tested a novel NMDAR-positive modulator, NYX-783, in the following two rodent...
9.
Yaeger J, Krupp K, Jacobs B, Onserio B, Meyerink B, Cain J, et al.
Biol Psychiatry
. 2022 Mar;
91(9):841-852.
PMID: 35279280
Background: Stress produces differential behavioral responses through select molecular modifications to specific neurocircuitry elements. The orexin (Orx) system targets key components of this neurocircuitry in the basolateral amygdala (BLA). Methods:...
10.
van Galen K, Booij J, Schrantee A, Adriaanse S, Unmehopa U, Fliers E, et al.
Metabolism
. 2021 Jul;
123:154839.
PMID: 34331964
Background And Aims: Serotonergic and dopaminergic systems in the brain are essential for homeostatic and reward-associated regulation of food intake and systemic energy metabolism. It is largely unknown how fasting...