Ralph Gruber
Overview
Explore the profile of Ralph Gruber including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
426
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0
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Recent Articles
1.
Ding M, Qing X, Zhang G, Baade-Buttner C, Gruber R, Lu H, et al.
Front Aging Neurosci
. 2022 Feb;
13:786199.
PMID: 35153719
MRE11, RAD50, and NBS1 form the MRN complex in response to DNA damage to activate ATM, a gene responsible for Ataxia-Telangiectasia (A-T). Loss of any components of the MRN complex...
2.
Gruber R, Panayiotou R, Nye E, Spencer-Dene B, Stamp G, Behrens A
Gastroenterology
. 2016 May;
151(3):526-39.
PMID: 27215660
Background & Aims: Pancreatitis is the most important risk factor for pancreatic ductal adenocarcinoma (PDAC). Pancreatitis predisposes to PDAC because it induces a process of acinar cell reprogramming known as...
3.
Sancho R, Gruber R, Gu G, Behrens A
Cell Stem Cell
. 2014 Aug;
15(2):139-53.
PMID: 25105579
The adult pancreas is capable of limited regeneration after injury but has no defined stem cell population. The cell types and molecular signals that govern the production of new pancreatic...
4.
Zhou Z, Tapias A, Bruhn C, Gruber R, Sukchev M, Wang Z
DNA Repair (Amst)
. 2013 May;
12(8):645-55.
PMID: 23683352
MCPH1 encodes BRCT-containing protein MCPH1/Microcephalin/BRIT1, mutations of which in humans cause autosomal recessive disorder primary microcephaly type 1 (MCPH1), characterized by a congenital reduction of brain size particularly in the...
5.
Gruber R, Zhou Z, Sukchev M, Joerss T, Frappart P, Wang Z
Nat Cell Biol
. 2011 Sep;
13(11):1325-34.
PMID: 21947081
Primary microcephaly 1 is a neurodevelopmental disorder caused by mutations in the MCPH1 gene, whose product MCPH1 (also known as microcephalin and BRIT1) regulates DNA-damage response. Here we show that...
6.
Gatz S, Ju L, Gruber R, Hoffmann E, Carr A, Wang Z, et al.
J Neurosci
. 2011 Jul;
31(27):10088-100.
PMID: 21734301
The embryonic ventricular and subventricular zones (VZ/SVZ) contain the neuronal stem and progenitor cells and undergo rapid proliferation. The intermediate zone (IZ) contains nonreplicating, differentiated cells. The VZ/SVZ is hypersensitive...
7.
Galron R, Gruber R, Lifshitz V, Lu H, Kirshner M, Ziv N, et al.
J Mol Neurosci
. 2011 Feb;
45(2):202-11.
PMID: 21279473
Nijmegen breakage syndrome (NBS) is a genomic instability disorder caused by hypomorphic mutations in the Nbs1 gene. When Nbs1 is conditionally inactivated in the central nervous system of mice (Nbs1-CNS-Δ),...