Ralf Pasternack
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Explore the profile of Ralf Pasternack including associated specialties, affiliations and a list of published articles.
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21
Citations
236
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Recent Articles
1.
Dotsenko V, Tewes B, Hils M, Pasternack R, Isola J, Taavela J, et al.
Nat Immunol
. 2024 Jun;
25(7):1218-1230.
PMID: 38914866
Transglutaminase 2 (TG2) plays a pivotal role in the pathogenesis of celiac disease (CeD) by deamidating dietary gluten peptides, which facilitates antigenic presentation and a strong anti-gluten T cell response....
2.
Isola J, Maki M, Hils M, Pasternack R, Viiri K, Dotsenko V, et al.
Int J Mol Sci
. 2023 Jul;
24(13).
PMID: 37445994
The enzyme transglutaminase 2 (TG2) plays a key role in celiac disease (CeD) pathogenesis. Active TG2 is located mainly extracellularly in the lamina propria but also in the villous enterocytes...
3.
Buchold C, Hils M, Gerlach U, Weber J, Pelzer C, Heil A, et al.
Cells
. 2022 May;
11(10).
PMID: 35626704
ZED1227 is a small molecule tissue transglutaminase (TG2) inhibitor. The compound selectively binds to the active state of TG2, forming a stable covalent bond with the cysteine in its catalytic...
4.
Leitner M, Buchold C, Pasternack R, Binder N, Moore G
Int J Mol Sci
. 2021 Jan;
22(3).
PMID: 33498248
Hereditary factor XIII (FXIII) deficiency is a rare autosomal bleeding disorder which can cause life-threatening bleeding. Acquired deficiency can be immune-mediated or due to increased consumption or reduced synthesis. The...
5.
6.
Staffler R, Pasternack R, Hils M, Kaiser W, Moller F
Anal Biochem
. 2020 Jul;
605:113719.
PMID: 32697952
Function, activity, and interactions of proteins crucially depend on their three-dimensional structure and are often regulated by effector binding and environmental changes. Tissue transglutaminase (Transglutaminase 2, TG2) is a multifunctional...
7.
Leitner M, Buchold C, Pasternack R, Binder N
Anal Biochem
. 2020 May;
600:113757.
PMID: 32422134
Plasma transglutaminase FXIII provides mechanical and biochemical stability to blood clots. Congenital or acquired deficiency may be associated with bleeding diathesis and requires therefore careful monitoring. The precise automated measurement...
8.
Stieler M, Buchold C, Schmitt M, Heine A, Hils M, Pasternack R, et al.
ChemMedChem
. 2020 Mar;
15(10):900-905.
PMID: 32181986
Blood coagulation factor XIII (FXIII, F13) is considered to be a promising target for anticoagulants with reduced bleeding risk because of its unique position in the coagulation cascade downstream of...
9.
Pasternack R, Buchold C, Jahnig R, Pelzer C, Sommer M, Heil A, et al.
J Thromb Haemost
. 2019 Oct;
18(1):191-200.
PMID: 31578814
Background: Factor XIII (FXIII) is the final enzyme of the coagulation cascade. While the other enzymatic coagulation factors are proteases, FXIII belongs to the transglutaminase family. FXIIIa covalently crosslinks the...
10.
van der Wildt B, Wilhelmus M, Beaino W, Kooijman E, Schuit R, Bol J, et al.
EJNMMI Res
. 2018 May;
8(1):39.
PMID: 29802556
Background: The protein cross-linking enzyme tissue transglutaminase (TG2; EC 2.3.2.13) is associated with the pathogenesis of various diseases, including cancer. Recently, the synthesis and initial evaluation of two high-potential radiolabelled...