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Martin Hils

Explore the profile of Martin Hils including associated specialties, affiliations and a list of published articles. Areas
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Articles 17
Citations 240
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Recent Articles
1.
Dotsenko V, Tewes B, Hils M, Pasternack R, Isola J, Taavela J, et al.
Nat Immunol . 2024 Jun; 25(7):1218-1230. PMID: 38914866
Transglutaminase 2 (TG2) plays a pivotal role in the pathogenesis of celiac disease (CeD) by deamidating dietary gluten peptides, which facilitates antigenic presentation and a strong anti-gluten T cell response....
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Isola J, Maki M, Hils M, Pasternack R, Viiri K, Dotsenko V, et al.
Int J Mol Sci . 2023 Jul; 24(13). PMID: 37445994
The enzyme transglutaminase 2 (TG2) plays a key role in celiac disease (CeD) pathogenesis. Active TG2 is located mainly extracellularly in the lamina propria but also in the villous enterocytes...
3.
Buchold C, Hils M, Gerlach U, Weber J, Pelzer C, Heil A, et al.
Cells . 2022 May; 11(10). PMID: 35626704
ZED1227 is a small molecule tissue transglutaminase (TG2) inhibitor. The compound selectively binds to the active state of TG2, forming a stable covalent bond with the cysteine in its catalytic...
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Staffler R, Pasternack R, Hils M, Kaiser W, Moller F
Anal Biochem . 2020 Jul; 605:113719. PMID: 32697952
Function, activity, and interactions of proteins crucially depend on their three-dimensional structure and are often regulated by effector binding and environmental changes. Tissue transglutaminase (Transglutaminase 2, TG2) is a multifunctional...
6.
Stieler M, Buchold C, Schmitt M, Heine A, Hils M, Pasternack R, et al.
ChemMedChem . 2020 Mar; 15(10):900-905. PMID: 32181986
Blood coagulation factor XIII (FXIII, F13) is considered to be a promising target for anticoagulants with reduced bleeding risk because of its unique position in the coagulation cascade downstream of...
7.
Pasternack R, Buchold C, Jahnig R, Pelzer C, Sommer M, Heil A, et al.
J Thromb Haemost . 2019 Oct; 18(1):191-200. PMID: 31578814
Background: Factor XIII (FXIII) is the final enzyme of the coagulation cascade. While the other enzymatic coagulation factors are proteases, FXIII belongs to the transglutaminase family. FXIIIa covalently crosslinks the...
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Heil A, Ohsam J, van Genugten B, Diez O, Yokoyama K, Kumazawa Y, et al.
J Agric Food Chem . 2017 Jul; 65(32):6982-6990. PMID: 28721717
The effect of standard bakery concentrations of microbial transglutaminase (MTG) in wheat bread preparation on the immunoreactivity of sera of celiac disease (CD) patients was investigated. Immunoblotting using monoclonal antibodies...
10.
Ruh T, Ohsam J, Pasternack R, Yokoyama K, Kumazawa Y, Hils M
J Agric Food Chem . 2014 Jul; 62(30):7604-11. PMID: 24998318
The effect of microbial transglutaminase (MTG)-treatment of pasta-dough on the immunoreactivity with celiac disease patient's sera has been investigated. Modification by MTG has been proven by determination of the MTG...