Ralf A Claus
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Explore the profile of Ralf A Claus including associated specialties, affiliations and a list of published articles.
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84
Citations
1574
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Recent Articles
1.
Grunewald B, Wickel J, Hahn N, Rahmati V, Rupp H, Chung H, et al.
Mol Ther
. 2024 May;
32(7):2113-2129.
PMID: 38788710
Sepsis-associated encephalopathy (SAE) is a frequent complication of severe systemic infection resulting in delirium, premature death, and long-term cognitive impairment. We closely mimicked SAE in a murine peritoneal contamination and...
2.
Horn P, Radtke S, Metzing U, Steidl R, Sponholz C, Sommerfeld O, et al.
Biomedicines
. 2022 Dec;
10(12).
PMID: 36551906
Sepsis is defined by life-threatening organ dysfunction mediated by the host’s response to infection. This can result in septic dyslipidemia, which is involved in the neutralization of pathogen-related lipids. Knowledge...
3.
Van Bulck M, Brandt N, Claus R, Graler M, Brauer A
Int J Mol Sci
. 2022 Feb;
23(4).
PMID: 35216416
Loss of active synapses and alterations in membrane lipids are crucial events in physiological aging as well as in neurodegenerative disorders. Both are related to the abnormal aggregation of amyloid-beta...
4.
Sakai T, Herrmann N, Maintz L, Numm T, Welchowski T, Claus R, et al.
JID Innov
. 2022 Feb;
2(2):100092.
PMID: 35199091
Circulating phospholipids have been considered as biomarkers and therapeutic targets in multiple disorders. Atopic dermatitis (AD) is the most common inflammatory skin disease. Although there are numerous studies having addressed...
5.
Metzing U, von Loeffelholz C, Steidl R, Romeike B, Winkler R, Rauchfuss F, et al.
Sci Rep
. 2022 Jan;
12(1):504.
PMID: 35017615
We provide a descriptive characterization of the unfolded protein response (UPR) in skeletal muscle of human patients with peritoneal sepsis and a sepsis model of C57BL/6J mice. Patients undergoing open...
6.
Abusukhun M, Winkler M, Pohlmann S, Moerer O, Meissner K, Tampe B, et al.
Front Immunol
. 2022 Jan;
12:784989.
PMID: 34987511
Effective treatment strategies for severe coronavirus disease (COVID-19) remain scarce. Hydrolysis of membrane-embedded, inert sphingomyelin by stress responsive sphingomyelinases is a hallmark of adaptive responses and cellular repair. As demonstrated...
7.
Konig R, Kolte A, Ahlers O, Oswald M, Krauss V, Roell D, et al.
Front Immunol
. 2021 Mar;
12:607217.
PMID: 33767693
Large clinical trials testing hydrocortisone therapy in septic shock have produced conflicting results. Subgroups may benefit of hydrocortisone treatment depending on their individual immune response. We performed an exploratory analysis...
8.
Sakai T, Herrmann N, Maintz L, Numm T, Welchowski T, Claus R, et al.
Allergy
. 2021 Mar;
76(8):2592-2595.
PMID: 33764548
No abstract available.
9.
Claus R, Graeler M
Front Med (Lausanne)
. 2021 Feb;
7:616578.
PMID: 33553212
Sphingolipids are a highly diverse group of lipids with respect to physicochemical properties controlling either structure, distribution, or function, all of them regulating cellular response in health and disease. Mass...
10.
Chung H, Claus R
Front Med (Lausanne)
. 2021 Feb;
7:616500.
PMID: 33553211
Breakdown of the inert and constitutive membrane building block sphingomyelin to the highly active lipid mediator ceramide by extracellularly active acid sphingomyelinase is tightly regulated during stress response and opens...